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TranscriptomicsThe effects of a novel agrochemical in alleviating salinity stress
Yield losses as a result of abiotic stress factors present a significant challenge for the future of global food production. While breeding technologies provide potential to combat negative stress-mediated outcomes over time, interventions which act to prime plant tolerance to stress, via the use of...
ORGANISM(S): Solanum lycopersicum 
2013-01-15 | E-GEOD-43492 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of lung from wild type and Mt1(-/-)Mt2(-/-) double knock-out mice after nickel aerosol exposure for 3, 8, 24, 48, and 72 hrs
Wildtype and Mt1(-/-)Mt2(-/-) double knockout 129S1/SvImJ strain mouse lungs were compared in their response to nickel aerosol exposure at 3, 8, 24, 48, and 72 hrs.
ORGANISM(S): Mus musculus 
2006-08-02 | E-MEXP-816 | biostudies-arrayexpress
MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
TranscriptomicsMicroarray expression data from human renal mesangial cells (HMC) treated with a Cyclosporine A (CsA) time course.
HMCs were treated with CsA (4.2 M-BM-5M) for 0 12 and 48 hours. To exmaine global gene changes in the renal mesangium following CsA treatment in order to identify novel contributors to CsA-induced renal dysfunction Microarray analysis was used to identify novel mechanisms of CsA nephrotoxicity in th...
ORGANISM(S): Homo sapiens 
2012-04-03 | E-GEOD-30952 | biostudies-arrayexpress
UnknownPhase I trial of lenalidomide and CCI-779 in patients with relapsed multiple myeloma: evidence for lenalidomide-CCI-779 interaction via P-glycoprotein.
Not available
S-EPMC3164245 | biostudies-literature
ProteomicsMudPIT analyses of proteins associated with Piccolo and Bassoon in the presynaptic active zone
We used a 3-step protocol that separates lipid-associated proteins based on their buoyant density, size and charge. All steps were conducted either on ice or at 4C. Step 1 involved a sucrose density gradient centrifugation in which ca. 100 postnatal day 4 rat brains were homogenized in buffer A (5...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2016-07-11 | MSV000079897 | MassIVE
MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
MetabolomicsELAPOR1 induces the classical/progenitor subtype and contributes to reduced disease aggressiveness through metabolic reprogramming in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous disease with distinct molecular subtypes described as classical/progenitor and basal-like/squamous PDAC. We hypothesized that integrative transcriptome and metabolome approaches can identify candidate genes whose inactivation contributes to ...
2024-04-02 | MTBLS9418 | MetaboLights
ProteomicsAAV Orbitrap CD-MS for AAV2, AAV6, and AAV8
CD-MS analysis collected on an Orbitrap UHMR. Note, this data was collected on a beta version of the DMT software and thus contains STORI files stored in separate zip files. The DMT files are also included as supplemental files, along with the UniDecCD processing parameters.
ORGANISM(S): Adeno-associated Dependoparvovirus A (ncbitaxon:1511891) 
2023-04-05 | MSV000091650 | MassIVE
ProteomicsTransmission of Cricket paralysis virus via exosome-like vesicles during infection of Drosophila cells
Examining the role of exosomes in the life cycle of CrPV in Drosophila Melanogaster. sing prquantitative proteomics we find CrPV proteins in exosome-like vesicles, which upon further aanalysis appear to facilitate infection.
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2018-11-14 | PXD011271 | Pride
Exosomes Drosophila Virus Crpv 
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