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TranscriptomicsSuppression of LPS-induced IFNg and NO in splenocytes by select E2-regulated miRNA: A novel mechanism of immune mod.
microRNA (miRNA), recently identified, non-coding, small RNA, are emerging as key regulators in homeostasis of the immune system. Therefore, aberrant expression of miRNA may be linked to immune dysfunction, such as in chronic inflammation and autoimmunity. In this study, we investigated the potent...
ORGANISM(S): Mus musculus 
2008-12-04 | E-GEOD-11197 | biostudies-arrayexpress
TranscriptomicsCharacterization of an Entamoeba histolytica High-Mobility-Group Box Protein Induced during Intestinal Infection
The unicellular eukaryote Entamoeba histolytica is a human parasite that causes amebic dysentery and liver abscess. A genome-wide analysis of gene expression modulated by intestinal colonization and invasion identified an up-regulated transcript that encoded a putative high-mobility-group box (HMGB)...
ORGANISM(S): Entamoeba histolytica 
2008-11-19 | E-GEOD-12204 | biostudies-arrayexpress
TranscriptomicsGene expression associated with liver metabolism during viral hemorrhagic fever
Rhesus macaques (Macaca mulatta) infected with a lethal dose of lymphocytic choriomeningitis virus-strain WE (LCMV-WE) provide a model for Lassa fever virus infection of man. Like Lassa fever in human beings, disease begins with flu-like symptoms but can progress to morbidity fairly rapidly. Previ...
ORGANISM(S): Macaca mulatta 
2010-06-16 | E-GEOD-12254 | biostudies-arrayexpress
TranscriptomicsTranscriptome Analysis of Human Peripheral Blood Mononuclear Cells Exposed to Lassa Virus and to the Reassortant ML29, a Vaccine Candidate
The virulent Lassa fever virus (LASV) and the non-pathogenic Mopeia virus (MOPV) infect rodents and incidentally people in West Africa. The mechanism of LASV damage in human beings is unclear. A live-attenuated reassortant of MOPV and LASV protects rodents and primates from Lassa fever disease. Peri...
ORGANISM(S): Homo sapiens 
2013-11-05 | E-GEOD-41300 | biostudies-arrayexpress
TranscriptomicsTargets of the E. histolytica transcription factor URE3-BP
The E. histolytica transcription factor URE3-BP is a calcium-responsive regulator of two E. histolytica virulence genes, hgl5 and fdx1. URE3-BP was previously identified by a yeast one-hybrid screen of E. histolytica proteins capable of binding to the sequence TATTCTATT (URE3) in the promoter region...
ORGANISM(S): Entamoeba histolytica 
2008-10-14 | E-GEOD-12188 | biostudies-arrayexpress
TranscriptomicsMembers of the Entamoeba histolytica transmembrane kinase family play non-redundant roles in growth and phagocytosis
Entamoeba histolytica contains a large and novel family of transmembrane kinases (TMK) with proposed roles that include both amebic response to the environment and immune evasion. In the later case, the process requires several elements --these include a large gene family encoding antigenically dist...
ORGANISM(S): Entamoeba histolytica 
2010-11-01 | E-GEOD-19064 | biostudies-arrayexpress
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