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TranscriptomicsGene expression profiling of EZH2 mutant and wild type DLBCL cell lines treated with EZH2 inhibitor
We studied transcriptional changes by Affymetrix human microarrays in DLBCL cell lines as a result of treatment with GSK126, a potent, highly-selective, SAM-competitive, small molecule inhibitor of EZH2 In eukaryotes, epigenetic post-translational modification of histones is critical for regulation ...
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-40971 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of two DLBCL cell lines upon shRNA mediated knockdown of EZH2
We studied transcriptional changes by Affymetrix human microarrays in 2 DLBCL cell lines as a result of shRNA mediated knockdown of EZH2. In eukaryotes, epigenetic post-translational modification of histones is critical for regulation of chromatin structure and gene expression. EZH2 is the catalytic...
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-41239 | biostudies-arrayexpress
TranscriptomicsEZH2 Inhibition as a Therapeutic Strategy for Lymphoma with EZH2 Activating Mutations
This SuperSeries is composed of the following subset Series: GSE40970: ChIP-seq analysis of H3K27me3 histone modification in EZH2 mutant and wild type DLBCL cell lines GSE40971: Gene expression profiling of EZH2 mutant and wild type DLBCL cell lines treated with EZH2 inhibitor GSE41239: Gene express...
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-40972 | biostudies-arrayexpress
GenomicsChIP-seq analysis of H3K27me3 histone modification in EZH2 mutant and wild type DLBCL cell lines
In eukaryotes, epigenetic post-translational modification of histones is critical for regulation of chromatin structure and gene expression. EZH2 is the catalytic subunit of the Polycomb Repressive Complex 2 (PRC2) and is responsible for repressing target gene expression through methylation of histo...
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-40970 | biostudies-arrayexpress
TranscriptomicsGene expression study in Neuroblastoma after BET inhibition
We studied transcriptional changes by Illumina HumanHT-12 v4 microarrays in 2 Neuroblastoma cell lines after i-BET-726 treatment 2 neuroblastoma cell lines SK-N-SH and CHP-212 were treated with i-BET-726 at 100nM or 1uM concentrations for 16 hrs to study gene expression.
ORGANISM(S): Homo sapiens 
2013-08-23 | E-GEOD-47386 | biostudies-arrayexpress
TranscriptomicsInhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer
We analyzed transcriptional changes in 4 prostate cancer cell lines following treatment with the BET inhibitor I-BET762 using Affymetrix Human Genome U133 Plus 2.0 Arrays. Four prostate cancer cell lines (NCI-H660, VCaP, LNCaP, PC-3) were treated with DMSO (control) or I-BET762 at 0.5uM or 10uM con...
ORGANISM(S): Homo sapiens 
2014-03-31 | E-GEOD-56352 | biostudies-arrayexpress
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