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MetabolomicsHypoxia Dependent Inhibition of Glioblastoma Cell Proliferation, Invasion, and Metabolism by the Choline-Kinase Inhibitor JAS239
Background: Elevated choline kinase alpha (ChoK) levels are observed in most solid tumors, including glioblastomas (GBM), and ChoK inhibitors have demonstrated limited efficacy in GBM models. Given that hypoxia is associated with resistance to GBM therapy, we hypothesized that tumor hypoxia c...
2024-06-18 | MTBLS6212 | MetaboLights
MetabolomicsThe ULK3 kinase is a key determinant of keratinocyte self-renewal and tumorigenesis targeting the arginine methylome
Epigenetic mechanisms oversee epidermal homeostasis and oncogenesis. The identification of kinases controlling these processes has direct therapeutic implications. We show that ULK3 is a nuclear kinase with elevated expression levels in squamous cell carcinomas (SCCs) arising in multiple body sites,...
2022-11-14 | MTBLS5155 | MetaboLights
TranscriptomicsEffect of acute creatine monohydrate supplementation on skeletal muscle transcriptome
Expression profiling of vastus lateralis muscle of young, healthy, non-obese men supplemented with creatine monohydrate vs. placebo for 10 days. Results identify transcriptional pathways activated in skeletal muscles as a result of acute creatine monohydrate supplementation. Keywords: Supplementatio...
ORGANISM(S): Homo sapiens 
2010-06-11 | E-GEOD-7877 | biostudies-arrayexpress
ProteomicsExogenous creatine supplementation promotes tumor metastasis via megakaryocyte creatine kinase B-STAT5B signaling
Creatine supplementation is widely used in sports and increasingly popular among exercising individuals. Although the physiological role of creatine has been extensively studied, the creatine biology in pathological status remains poorly understood. Here we report that exogenous creatine supplementa...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-27 | PXD065649 | Pride
TranscriptomicsCardiac muscle ring finger-1 increases susceptibility to heart failure by inhibiting creatine kinase activity in vivo
Muscle ring finger-1 (MuRF1) is a muscle-specific protein implicated in the regulation of cardiac myocyte size and contractility. MuRF2, a closely related family member, redundantly interacts with protein substrates, and hetero-dimerizes with MuRF1. Mice lacking either MuRF1 or MuRF2 are phenotypica...
ORGANISM(S): Mus musculus 
2009-06-03 | E-GEOD-11661 | biostudies-arrayexpress
MetabolomicsImmunoglobulin expression in the endoplasmic reticulum shapes the metabolic fitness of B lymphocytes
The major function of B lymphocytes is to sense antigens and to produce protective antibodies after activation. This function requires the expression of a B-cell antigen receptor (BCR), and evolutionary conserved mechanisms seem to exist that ensure that B cells without a BCR do not develop nor surv...
2020-04-21 | MTBLS186 | MetaboLights
MetabolomicsGDF15 hijacks B cells to fuel the lifeblood of tumor salvage pyrimidine synthesis
B cell-tumor crosstalk has emerged as a critical determinant of tumor progression; however, its role in metabolic reprogramming and therapeutic resistance remains poorly understood. Here, we uncover a metabolic feedback loop that drives resistance to dihydroorotate dehydrogenase (DHODH) inhibitors. ...
2026-09-27 | MTBLS15820 | MetaboLights
ProteomicsCreatine kinase B, a downstream effector of MYB, controls migration of osteosarcoma cells via regulation of N-cadherin
A study aimed at identification of proteins associated with CRISPR/Cas-induced depletion of creatine kinase B (CKB) in SAOS-LM5 metastatic osteosarcoma cell line using LC-MS/MS in data-independent acquisition (DIA)-parallel accumulation serial fragmentation (diaPASEF) mode. Here we prepared two KO c...
ORGANISM(S): Homo sapiens (Human) 
2026-01-23 | PXD065263 | Pride
Pasef Cell migration Creatine kinase b Data independent acquisition Osteosarcoma 
TranscriptomicsTranscription profiling of brains from mice fed with or without creatine supplementation to study the molecular mechanism of creatine improving health and life span in mice
Here we show that oral creatine (Cr) supplementation leads to increased life span in mice. Treated mice showed improved neurobehavioral performance, decreased accumulation of the aging pigment lipofuscin and upregulation of anti-aging genes in brain. As Cr is virtually free of adverse effects, it ma...
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-5140 | biostudies-arrayexpress
ProteomicsGPX4 immunoprecipitation in Huh7 cells
Huh7 cells with expression of Flag-GPX4 were treated with IGF1. An immunoprecipitation assay was performed, and immunoprecipitates were subjected to masspec analysis.
ORGANISM(S): Human 
2023-02-22 | MSV000091343 | MassIVE
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