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TranscriptomicsChromatin immunoprecipitation of human cell lines to identify cAMP-response element binding protein (CREB) binding sites.
Hormones and nutrients often induce genetic programs via signaling pathways that interface with gene-specific activators. Activation of the cAMP pathway, for example, stimulates cellular gene expression by means of the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB) at S...
ORGANISM(S): Homo sapiens 
2006-05-09 | E-WMIT-11 | biostudies-arrayexpress
TranscriptomicsExpression data from AsPC1 cells treated with ICG-001
The CREB binding protein inhibitor ICG-001 suppresses pancreatic cancer growth We used microarrays to detail global gene expression changes in the pancreatic cancer cell line AsPC1 following treatment with ICG-001 or siRNA-mediated knockdown of CTNNB1 (beta-catenin) AsPC1 cells were treated with 10u...
ORGANISM(S): Homo sapiens 
2014-07-15 | E-GEOD-57728 | biostudies-arrayexpress
TranscriptomicsThe transcription factor cyclic AMP–responsive element–binding protein H regulates triglyceride metabolism
Here we report that the transcription factor cyclic AMP–responsive element–binding protein H (CREB-H, encoded by CREB3L3) is required for the maintenance of normal plasma triglyceride concentrations. CREB-H–deficient mice showed hypertriglyceridemia secondary to inefficient triglyceride clearance ca...
ORGANISM(S): Mus musculus 
2011-06-04 | E-GEOD-29643 | biostudies-arrayexpress
TranscriptomicsCREB ChIP-chip and HaloCHIP-chip experiments
Regulation of gene expression is essential for normal development and cellular growth. Transcriptional events are tightly controlled both spatially and temporally by specific DNA-protein interactions. In this study we finely map the genome-wide targets of the CREB protein across all known and predi...
ORGANISM(S): Homo sapiens 
2010-05-22 | E-GEOD-18347 | biostudies-arrayexpress
TranscriptomicsTunable regulation of CREB DNA binding activity couples genotoxic stress response and metabolism
In this study we show that, in embryonic fibroblasts from mice on a high fat diet and treated with Forskolin, ionizing radiation exposure or both, phosphorylation of CREB-binding protein (CREB) by ATM (ataxia-telangiectasia-mutated) and casein kinases 1 and 2 (CK1 and CK2) on a cluster of five phosp...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-83891 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HEK293T to characterize CREB target genes in different tissue types
The CREB family of transcription factors stimulates cellular gene expression following phosphorylation at a conserved serine (Ser133 in CREB1) in response to cAMP and other extracellular signals. In order to characterize CREB target genes in various tissues, we give a cAMP agonist, forskolin (FSK), ...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-2060 | biostudies-arrayexpress
UnknownSmall molecule nAS-E targeting cAMP response element binding protein (CREB) and CREB-binding protein interaction inhibits breast cancer bone metastasis.
Not available
S-EPMC6349349 | biostudies-literature
UnknownStructural Analysis of a Complex between Small Ubiquitin-like Modifier 1 (SUMO1) and the ZZ Domain of CREB-binding Protein (CBP/p300) Reveals a New Interaction Surface on SUMO.
Not available
S-EPMC4933466 | biostudies-literature
TranscriptomicsMethylation specifies distinct estrogen-induced binding site repertoires of CBP to chromatin (mRNA)
Multiple signaling pathways ultimately modulate the epigenetic information embedded in the chromatin of gene promoters by recruiting epigenetic enzymes. We found that, in estrogen-regulated gene programming, the acetyltransferase CREB-binding protein (CBP) is specifically and exclusively methylated ...
ORGANISM(S): Homo sapiens 
2011-10-06 | E-GEOD-32348 | biostudies-arrayexpress
GenomicsMethylation specifies distinct estrogen-induced binding site repertoires of CBP to chromatin (ChIP-Seq)
Multiple signaling pathways ultimately modulate the epigenetic information embedded in the chromatin of gene promoters by recruiting epigenetic enzymes. We found that, in estrogen-regulated gene programming, the acetyltransferase CREB-binding protein (CBP) is specifically and exclusively methylated ...
ORGANISM(S): Homo sapiens 
2011-10-06 | E-GEOD-32349 | biostudies-arrayexpress
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