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TranscriptomicsTranscription profiling of human HeLa cells in response to IKAP/hELP1 siRNA transfection and/or tumor necrosis factor-a treatment
HeLa cells were un-transfected or transfected with specific siRNAs (20µM) targeting IKAP/hELP1 or non-specific siRNAs against GFP. Same experiment was done by stimulating the cells for 1 hour with TNF-a (200U/ml). conditions: 1/untransfected 2/siRNAs IKAP 3/untransfected + TNF-a 200U/ml 1h 4/siRNAs ...
ORGANISM(S): Homo sapiens 
2022-11-21 | E-MEXP-641 | biostudies-arrayexpress
GenomicsMacroH2A1 regulates the balance between self-renewal and differentiation commitment in embryonic and adult stem cells
One of the most striking epigenetic alterations that occurs at the level of the nucleosome is the complete exchange of the canonical H2A histones for the macroH2A variant. Here, we provide insight in the function of this unique histone variant in embryonic and adult stem cells. Knockdown of macroH2A...
ORGANISM(S): Mus musculus 
2012-02-20 | E-GEOD-35087 | biostudies-arrayexpress
TranscriptomicsA Cbx8-containing Polycomb complex facilitates gene activation during ES cell differentiation [Agilent Array]
Polycomb proteins play an essential role in maintaining the repression of developmental genes in self-renewing embryonic stem cells. The exact mechanism allowing the derepression of polycomb target genes during cell differentiation remains unclear. Here, we show that several differentiation genes tr...
ORGANISM(S): Mus musculus 
2014-11-04 | E-GEOD-54051 | biostudies-arrayexpress
GenomicsGenome-wide hydroxymethylcytosine pattern changes in response to oxidative stress
The TET-family enzymes (TETs) convert methylcytosine to hydroxymethylcytosine, a lately discovered epigenetic modification that can modulate transcription. While recent reports suggest that TETs may play a role in response to oxidative stress, this role remains uncertain. Here we show that Tet1 is s...
ORGANISM(S): Homo sapiens 
2016-01-14 | E-GEOD-59718 | biostudies-arrayexpress
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