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TranscriptomicsSingle cell RNAseq analysis of anti-Vaccinia long-lived memory B cells (CEL-seq2)
Memory B cells represent one of the pillar of humoral protection and are found in the circulation and secondary lymphoid organs several decades after initial pathogen or vaccine encounter. The exact cellular and biological mechanisms allowing long-term survival of quiescent cells in such a fluctuati...
ORGANISM(S): Homo sapiens 
2022-09-19 | E-MTAB-11626 | biostudies-arrayexpress
Transcriptomicssingle cell RNAseq of memory B cells in the context of rituximab-treated ITP patients
Rituximab (RTX) is widely used as a first-line therapeutic strategy in B cell-mediated autoimmune diseases. However, a large proportion of patients either do not respond to the treatment or relapse during B cell reconstitution. Primary immune thrombocytopenia (ITP) is a prototypic B cell mediated au...
ORGANISM(S): Homo sapiens 
2021-01-31 | E-MTAB-9955 | biostudies-arrayexpress
TranscriptomicsATAC-seq analysis of quiescent human splenic B cell populations
Memory B cells represent one of the pillar of humoral protection and are found in the circulation and secondary lymphoid organs several decades after initial pathogen or vaccine encounter. The exact cellular and biological mechanisms allowing long-term survival of quiescent cells in such a fluctuati...
ORGANISM(S): Homo sapiens 
2022-09-19 | E-MTAB-11625 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of quiescent human splenic B cell populations
Memory B cells represent one of the pillar of humoral protection and are found in the circulation and secondary lymphoid organs several decades after initial pathogen or vaccine encounter. The exact cellular and biological mechanisms allowing long-term survival of quiescent cells in such a fluctuati...
ORGANISM(S): Homo sapiens 
2022-09-19 | E-MTAB-11622 | biostudies-arrayexpress
TranscriptomicsLongitudinal scRNAseq profiling of memory B cells in severe COVID19 patients
Memory B cells play a fundamental role in host defences against viruses. This dataset aimed at understanding their maturation and stability in the context of SARS-CoV-2 infection and consist of a longitudinal single-cell and repertoire profiling of the B cell response up to six months in four severe...
ORGANISM(S): Homo sapiens 
2021-01-31 | E-MTAB-9995 | biostudies-arrayexpress
TranscriptomicsLongitudinal scRNAseq profiling of memory B cells in mRNA vaccinated individuals post BA.1-breakthrough infection
Memory B cells play a fundamental role in host defenses against viruses. This dataset aimed at understanding the recruitment and remodeling of the memory B cell repertoire in the context of BA.1-breakthrough infection in BNT162b2 mRNA vaccinated individuals. All four donors enrolled in the study had...
ORGANISM(S): Homo sapiens 
2023-08-15 | E-MTAB-12651 | biostudies-arrayexpress
TranscriptomicsAntibody mRNA-seq repertoire sequencing to study relapses after B-cell depletion therapy
Rituximab (RTX) is widely used as a first-line therapeutic strategy for patients affected by immune thrombocytopenia (ITP). However, a large proportion of patients relapse after successful treatment. The present NGS assay was done to help find the cause for this relapse on the immune repertoire leve...
ORGANISM(S): Homo sapiens 
2021-01-18 | E-MTAB-9953 | biostudies-arrayexpress
TranscriptomicsBAFF and CD4+ T cells are major survival factors for long-lived splenic plasma cells in a B-cell–depletion context
Previous data have suggested that B-cell–depletion therapy may induce the settlement of autoreactive long-lived plasma cells (LLPCs) in the spleen of patients with autoimmune cytopenia. To investigate this process, we used the AID-CreERT2-EYFP mouse model to follow PCs engaged in an immune response....
ORGANISM(S): Mus musculus 
2018-02-19 | E-MTAB-6449 | biostudies-arrayexpress
UnknownRituximab-resistant splenic memory B cells and newly engaged naive B cells fuel relapses in patients with immune thrombocytopenia.
Not available
S-EPMC7610758 | biostudies-literature
UnknownMaturation and persistence of the anti-SARS-CoV-2 memory B cell response.
Not available
S-EPMC7994111 | biostudies-literature
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