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GenomicsPRC1.6 ChIPseq - HEK239
Components of the PRC1.6 complex were depleted via Crisper/Cas9 and ChIPed in HEK293 cells.
ORGANISM(S): Homo sapiens 
2018-01-24 | E-MTAB-6006 | biostudies-arrayexpress
GenomicsPRC1.6 ChIPseq - mouse ES
Components of the PRC1.6 complex were depleted via Crisper/Cas9 and ChIPed in mouse ES cells.
ORGANISM(S): Mus musculus 
2018-01-24 | E-MTAB-6007 | biostudies-arrayexpress
TranscriptomicsPRC1.6 RNAseq
MGA was depleted via Crisper/Cas9 in HEK293 cells and the resulting gene expression changes were profiled.
ORGANISM(S): Homo sapiens 
2018-01-24 | E-MTAB-6005 | biostudies-arrayexpress
TranscriptomicsTranscriptome sequencing of the hnRNPA2B1 knockout Huh7 cell line
To investigate the role of hnRNPA2B1 in the progression of hepatocellular carcinogenesis, we established a Huh7 cell line in which the hnRNPA2B1 gene was knocked out by crisper/cas9.
ORGANISM(S): Homo sapiens 
2023-09-01 | GSE226544 | GEO
TranscriptomicsComparison of gene expression profiles between SCD1/FADS2 knockdown and vector control of ovarian cancer cells OVCA433 by RNA-sequencing
To understand the dependence of ovarian tumor cells on fatty acid metabolism, we performed transcriptome analysis using OVCA433 ovarian cancer cells, in which SCD1/FADS2 was genetically ablated via CRISPER/Cas9.
ORGANISM(S): Homo sapiens 
2021-03-12 | GSE168720 | GEO
TranscriptomicsEffect of depletion of METTL16 on gene expression of Huh7 liver cancer cells [RNA-seq]
To investigate the mechanism of METTL16 in the regulation of tranlation and HCC development, we established Huh7 cell lines following METTL16 knockout (KO) by CRISPER-Cas9 system. We then performed gene expression profiling analysis using data obtained from RNA-seq of Huh7 cells.
ORGANISM(S): Homo sapiens 
2024-01-30 | GSE224008 | GEO
TranscriptomicsEffect of knockout of SOX9 on gene expression profile in Huh7 cells
To investigate the effect of SOX9 on the expression profile of Huh-7 cells, we established SOX9 knockout (SOX9KO)Huh-7 cells by crisper-cas9 system.We then performed gene expression profiling analysis using data obtained from RNA-seq of Huh-7 and SOX9KO Huh-7 cells.
ORGANISM(S): Homo sapiens 
2022-10-01 | GSE214335 | GEO
TranscriptomicsTumorigenic effect of knockout HKDC1 on A549 in vivo
To investigate the tumorigenic function of HKDC1 in vivo, we established A549 cell lines in which HKDC1 has been knockout by CRISPER/Cas9 genome editing. We then performed gene expression profiling analysis using data obtained from RNA-seq of 6 different tumors from sgCtrl or sgHKDC1-1 groups.
ORGANISM(S): Homo sapiens 
2024-12-18 | GSE216107 | GEO
TranscriptomicsGenomic editing of pathogenic TNNI3 mutation in restrictive cardiomyopathy rescues diastolic dysfunction of human induced pluripotent stem cell-derived cardiomyocytes
To investigate the physiological characteristics of cardiomyocytes (CM) in restrictive cardiomyopathy (RCM), we established RCM(heterozygous)-iPSC and produced RCM(homozygous)-iPSC and corrected Isogenic-iPSC using CRISPER-CAS9 technology. Then, we used the RNA-seq data obtained from these three iPS...
ORGANISM(S): Homo sapiens 
2023-08-21 | GSE240775 | GEO
TranscriptomicsTranscriptome analysis of CHSY3 knockdown NP cells
Intervertebral disc degeneration is the main cause of low back pain and the mechanism of which is far from fully revealed. Although multiple factors are related to the intervertebral disc degeneration, inflammation and matrix metabolism dysregulation are the two key factors that play an important ro...
ORGANISM(S): Mus musculus 
2022-01-02 | GSE145649 | GEO
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