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ProteomicsIdentification of regulators of polyploidization presents therapeutic targetsfor treatment of AMKL
Wen Q, Goldenson B, Silver SJ, Schenone M, Dancik V, Huang Z, Wang LZ, Lewis TA, An WF, Li X, Bray MA, Thiollier C, Diebold L, Gilles L, Vokes MS, Moore CB, Bliss-Moreau M, Verplank L, Tolliday NJ, Mishra R, Vemula S, Shi J, Wei L, Kapur R, Lopez CK, Gerby B, Ballerini P, Pflumio F, Gilliland DG, Go...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-01-27 | MSV000078536 | MassIVE
UnknownDYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3.
Not available
S-EPMC4451127 | biostudies-literature
UnknownUSP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism.
Not available
S-EPMC6071563 | biostudies-literature
UnknownModeling GATA2 deficiency in mice: the R396Q mutation disrupts normal hematopoiesis.
Not available
S-EPMC11879863 | biostudies-literature
ProteomicsProteomics profiling of human CD34+ cells from MDS bone marrow and healthy control cells
Myelodysplastic syndromes (MDS) are a heterogeneous group of hematopoietic disorders characterized by ineffective blood cell production and a high risk of progression to acute myeloid leukemia (AML). CD34+ hematopoietic stem and progenitor cells (HSPCs) play a critical role in the pathophysiology of...
ORGANISM(S): Homo sapiens (Human) 
2025-11-14 | PXD059857 | Pride
Dia proteomics Npm1 Myelodysplastic syndromes Leukemia Mds fbxo11 
UnknownPosttranslational regulation of FOXA1 by Polycomb and BUB3/USP7 deubiquitin complex in prostate cancer.
Not available
S-EPMC8026124 | biostudies-literature
GenomicsIdentification of ETO2-GLIS2 targets by ChIP-sequencing
Acute megakaryoblastic leukemia (AMKL) is a subtype of leukemia primarily diagnosed in childhood and generally associated with poor prognosis. Genetic alterations found in de novo childhood AMKL include the OTT-MAL fusion, MLL and NUP98 fusions and the recently identified ETO2-GLIS2 fusion that invo...
ORGANISM(S): Homo sapiens 
2017-05-22 | E-MTAB-4367 | biostudies-arrayexpress
TranscriptomicsIdentification of ETO2-GLIS2 transcriptional targets
Acute megakaryoblastic leukemia (AMKL) is a subtype of leukemia primarily diagnosed in childhood and generally associated with poor prognosis. Genetic alterations found in de novo childhood AMKL include the OTT-MAL fusion, MLL and NUP98 fusions and the recently identified ETO2-GLIS2 fusion that invo...
ORGANISM(S): Homo sapiens 
2017-05-05 | E-MTAB-4332 | biostudies-arrayexpress
UnknownLoss of Function Mouse Models Reveal a Novel Regulatory Function for ULK1 in Myeloproliferative Neoplasms.
Not available
S-EPMC12645588 | biostudies-literature
UnknownCharacterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models.
Not available
S-EPMC3478932 | biostudies-literature
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