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TranscriptomicsAML with mutated NPM1 carrying a normal or aberrant karyotype show overlapping features
AML with mutated NPM1 usually carries normal karyotype (NK) but it may harbor chromosomal aberrations whose significance remains unclear. We addressed this question in 631 AML patients with mutated/cytoplasmic NPM1. An abnormal karyotype (AK) was present in 93/631 cases (14.7%), the most frequent ab...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-GEOD-16015 | biostudies-arrayexpress
TranscriptomicsNPM1 mutation-modulated microRNA−mRNA regulation in acute myeloid leukemia [mRNA]
Mutation in the nucleophosmin (NPM1) gene is frequent in acute myeloid leukemia (AML). This mutation has remarkable prognostic significance and correlates with distinct biological features. Our data from the sample-paired microRNA (miRNA) and mRNA microarrays of de novo AML patients strongly indicat...
ORGANISM(S): Homo sapiens 
2017-05-03 | E-GEOD-68466 | biostudies-arrayexpress
TranscriptomicsNPM1 mutation-modulated microRNA−mRNA regulation in acute myeloid leukemia [miRNA]
Mutation in the nucleophosmin (NPM1) gene is frequent in acute myeloid leukemia (AML). This mutation has remarkable prognostic significance and correlates with distinct biological features. Our data from the sample-paired microRNA (miRNA) and mRNA microarrays of de novo AML patients strongly indicat...
ORGANISM(S): Homo sapiens 
2017-05-03 | E-GEOD-68467 | biostudies-arrayexpress
TranscriptomicsTargeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia
Homeobox (HOX) proteins and the receptor tyrosine kinase FLT3 are frequently highly expressed and mutated in acute myeloid leukemia (AML). Aberrant HOX expression is found in nearly all AMLs that harbor a mutation in the Nucleophosmin (NPM1) gene, and FLT3 is concomitantly mutated in approximately 6...
ORGANISM(S): Homo sapiens 
2016-08-22 | E-GEOD-85107 | biostudies-arrayexpress
TranscriptomicsGeneration of NPM1-ALK translocation in human T lymphocytes faithfully recapitulates the diversity of ALK+ ALCL tumor phenotype
To recapitulate the t(2;5)(p23;q35) chromosomal translocation, activated T lymphocytes from healthy donors PBMC were transfected with the RNP complex composed of the protein Cas9 with gRNA NPM1 (targeting NPM1 gene) and gRNA ALK (targeting ALK gene). Control cells were wild-type CD4+ activated lymp...
ORGANISM(S): Homo sapiens 
2022-02-09 | E-MTAB-10924 | biostudies-arrayexpress
TranscriptomicsMultilineage dysplasia and AML with mutated nucleophosmin
Multilineage dysplasia (MLD) has no impact on biological, clinico-pathological and prognostic features of AML with mutated nucleophosmin (NPM1) NPM1-mutated AML is a provisional entity in the WHO-2008 classification of myeloid neoplasms. The significance of concomitant multilineage dysplasia (MLD) i...
ORGANISM(S): Homo sapiens 
2010-07-30 | E-GEOD-18018 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of human acute myeloid leukemia samples from patients characterized for subcellular localization/mutation status of NPM1 and FLT3 mutations
Acute myeloid leukemia (AML) carrying NPM1 mutations and cytoplasmic nucleophosmin (NPMc+ AML) accounts for about one-third of adult AML and shows distinct features, including a unique gene expression profile. MicroRNAs (miRNAs) are small noncoding RNAs of 19-25 nucleotides in length that have been ...
ORGANISM(S): Homo sapiens 
2008-03-14 | E-TABM-429 | biostudies-arrayexpress
TranscriptomicsNPM1 mutation-modulated microRNA-mRNA regulation in acute myeloid leukemia
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2017-05-03 | E-GEOD-68469 | biostudies-arrayexpress
ProteomicsRibosome biogenesis factors are post-transcriptionally depleted in NPM1-mutant acute myeloid leukemia and can be targeted therapeutically
Mutations in the NPM1 gene are found in more than 30% of acute myeloid leukemia (AML) cases. The mutations disrupt a nucleolar localization signal (NoLS) and create a novel nuclear export signal (NES), leading to cytoplasmic displacement of the protein (NPM1c). NPM1c mutations prime hematopoietic pr...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-27 | PXD053249 | Pride
Npm1 Proteomics Tmt Ribososme biogenesis 
GenomicsDHX9 and NPM1 silencing RNA-seq
DHX9 and NPM1 silencing RNA-seq
PRJNA512873 | ENA
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