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TranscriptomicsPyrococcus furiosus crRNAs associated with Cmr, Csa and Cst CRISPR-Cas systems
CRISPR-Cas immune systems function to defend prokaryotes against potentially harmful mobile genetic elements including viruses and plasmids. The multiple CRISPR-Cas systems (Types I, II, III) each recognize and target destruction of foreign invader nucleic acids via structurally and functionally div...
ORGANISM(S): Pyrococcus furiosus 
2015-07-10 | E-GEOD-65781 | biostudies-arrayexpress
ProteomicsType III-B CRISPR-Cas signaling-based cascade of proteolytic cleavages
Characteristic for type III CRISPR-Cas systems is the generation of cyclic oligoadenylate (cOA) molecules, which allosterically activate proteins carrying cognate sensory domains: CARF or SAVED. Here, we characterize a type III-B system associated set of genes from Haliangium ochraceum, containing t...
ORGANISM(S): Haliangium ochraceum DSM 14365 
2025-05-06 | PXD046897 | Pride
Type iii crispr-cas 
TranscriptomicsDeep sequencing data for PAM-SCANR tested CRISPR-Cas systems
In this work, we analyzed recognized PAM sequences from four CRISPR-Cas systems: E. coli I-E, B. halodurans I-C, S. thermophilus CR1 II-A, and F. novicida V. Cells containing functional PAMs were sorted using FACS and subsequently sequenced. Ranking of recognized PAMs from a positive screen
ORGANISM(S): Francisella tularensis subsp. novicida 
2016-02-17 | E-GEOD-75718 | biostudies-arrayexpress
GenomicsAnti-CRISPR phages cooperate to overcome CRISPR-Cas immunity
Anti-CRISPR phages cooperate to overcome CRISPR-Cas immunity
PRJEB25016 | ENA
GenomicsVibrio Cholerae CRISPR-cas PAM requirements
Vibrio Cholerae CRISPR-cas PAM requirements
PRJEB75322 | ENA
GenomicsEvolutionary loss of CRISPR-Cas
Mixed mode transmission of phages drives loss of Type I CRISPR-Cas immune systems from bacteria
PRJEB34503 | ENA
TranscriptomicsPyrococcus furiosus crRNAs associated with the Cas RAMP module complex
Analysis of CRISPR RNAs from both total Pyrococcus furiosus RNA and those that co-purify with the Cmr complex, which has been predicted to be involved in RNA-mediated targeting of foreign RNAs in prokaryotes. Small RNAs (20 - 70 nts) were isolated either from total Pyrococcus furiosus RNA or RNAs i...
ORGANISM(S): Pyrococcus furiosus 
2012-01-31 | E-GEOD-33256 | biostudies-arrayexpress
GenomicsCRISPR-Cas GB model
CRISPR-Cas provides limited phage immunity to a prevalent gut bacterium in gnotobiotic mice
PRJEB47947 | ENA
ProteomicsStructure of the minimal type I-F2 CRISPR-Cas DNA-interference complex
CRISPR–Cas systems provide adaptive immunity in prokaryotes by targeting and degrading invasive genetic elements. Among them, the type I-F2 system represents the most compact type I CRISPR–Cas system, distinguished by the absence of small and large subunits. These subunits are otherwise essential fo...
ORGANISM(S): Shewanella putrefaciens CN-32 
2026-03-09 | PXD068253 | Pride
Cryo-em Shewanella putrefaciens Hdx-ms Dna interference Interference complex 
ProteomicsControl of a type III-Dv CRISPR-Cas system by the transcription factor RpaB and interaction of its transcribed leader with the DEAD-box RNA helicase CrhR
CRISPR-Cas systems in bacteria and archaea provide powerful defense against phages and other foreign genetic elements. The principles of CRISPR-Cas activity are well understood, but less is known about how their expression is regulated. The cyanobacterium Synechocystis sp. PCC 6803 encodes three sep...
ORGANISM(S): Synechocystis sp. (strain PCC 6803 / Kazusa) 
2024-07-15 | PXD047440 | Pride
Cyanobacteria Crhr dead-box rna helicase Crispr leader Transcription factor rpab Crispr-cas systems Regulation of crispr-cas gene expression  rna structure 
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