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The var multigene family encodes clonally variant surface antigens that are key to immune evasion and pathogenesis in the human malaria parasite, Plasmodium falciparum. Epigenetics and nuclear organization regulate the var gene family in a system of mutually exclusive expression; however, few factor...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2020-07-15 | PXD013131 | Pride
We report the generation of CRISPR-dCas9 DNA methyltransferases to mediate targeted DNA methylation. Using the dCas9-BFP-DNMT3A and dCas9-BFP-DNMT3B methyltransferases, we have demonstrated that these two methyltransferase can mediate targeted methylation in three human genes tested: uPA, TGFBR3, an...
ORGANISM(S): Homo sapiens 
Chem-CRISPR/dCas9 -a chemically induced platform for epigenome editing
Expanding the Scope of Bacterial CRISPR Activation with PAM-flexible dCas9 Variants
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