Sort   by:  
 Page size 
MetabolomicsWhole genome CRISPRi screening identifies druggable vulnerabilities in drug-resistant Mycobacterium tuberculosis

Tuberculosis (TB) remains a global health threat, aggravated by the emergence of drug-resistant strains. This study aims to identify genes and metabolic pathways with increased vulnerability in drug-resistant Mycobacterium tuberculosis strains compared to their drug-susceptible counterparts. Usin...

2024-10-15 | MTBLS11277 | MetaboLights
GenomicsPervasive off-target activity in CRISPR-interference (CRISPRi) system [RNA-seq]
Pervasive off-target activity in CRISPR-interference (CRISPRi) system [RNA-seq]
PRJNA1063363 | ENA
GenomicsPervasive off-target activity in CRISPR-interference (CRISPRi) system [ChIP-seq]
Pervasive off-target activity in CRISPR-interference (CRISPRi) system [ChIP-seq]
PRJNA1063362 | ENA
UnknownCorynebacterium glutamicum Metabolic Engineering with CRISPR Interference (CRISPRi).
Not available
S-EPMC4877668 | biostudies-literature
GenomicsNext-Generation Sequencing of sgRNA spacer sequences from a CRISPRi library screen of the Salmonella enterica serovar Typhimurium 14028s genome in response to repeated monoclonal IgA treatment
For this study, we implemented the anti-lipopolysaccharide monoclonal IgA Sal4 in a genome-wide CRISPR interference (CRISPRi) screen to identify genes that modulate the extent of agglutination of Salmonella enterica serovar Typhimurium (STm) in response to antibody exposure. We leveraged our recentl...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2025-02-16 | E-MTAB-14834 | biostudies-arrayexpress
UnknownCRISPR interference (CRISPRi) as transcriptional repression tool for Hungateiclostridium thermocellum DSM 1313.
Not available
S-EPMC7017836 | biostudies-literature
UnknownAn improved CRISPR and CRISPR interference (CRISPRi) toolkit for engineering the model methanogenic archaeon Methanococcus maripaludis.
Not available
S-EPMC11373211 | biostudies-literature
TranscriptomicsRNA-seq of CSMD1 enhancer CRISPRi in LUHMES cells and differentiated neurons
we performed lentiviral CRISPR interference (CRISPRi) by recruiting dCas9 fused with the KRAB domain to the CSMD1 enhancer (fam3) in the neuronal precursor cell line – Lund human mesencephalic (LUHMES). Given that the expression of CSMD1 was not detectable in LUHMES cells we differentiated these cel...
ORGANISM(S): Homo sapiens 
2022-06-30 | E-MTAB-8027 | biostudies-arrayexpress
ProteomicsValidating the use of CRISPR interference for the modulation of glycosylation in Burkholderia thailandensis
To determine whether CRISPR interference can be used to modulate glycosylation in Burkholderia thailandensis
ORGANISM(S): Burkholderia thailandensis E264 
2023-03-20 | PXD036623 | Pride
Glycosylation Burkholderia thailandensis Crispr interference Crispri 
ProteomicsValidating the use of CRISPR interference for the modulation of glycosylation in Burkholderia cenocepacia
To determine whether CRISPR interference can be used to modulation glycosylation in Burkholderia cenocepacia
ORGANISM(S): Burkholderia cenocepacia K56-2Valvano 
2023-03-20 | PXD036564 | Pride
Glycosylation Burkholderia cenocepacia Crispr interference Crispri 
Sort   by:  
 Page size