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GenomicsAmplicon Sequencing of gRNAs from Brunello CRISPR mutagenized A549 and U87-MG cells after live/dead selection with EV-D68 IL
With the near eradication of poliovirus due to global vaccination campaigns, attention has shifted to other enteroviruses that can cause polio-like paralysis syndrome (now termed acute flaccid myelitis (AFM)). In particular, enterovirus D68 (EV-D68) is believed to be the main driver of epidemic outb...
ORGANISM(S): Homo sapiens 
2025-02-25 | E-MTAB-14765 | biostudies-arrayexpress
ProteomicsMolecular dissection and testing of PRSS37 function through LC-MS/MS and the generation of a PRSS37 humanized mouse model
LC-MS/MS of Prss37 WT and KO mice male reproductive tract. Title: Molecular dissection and testing of PRSS37 function through LC-MS/MS and the generation of a PRSS37 humanized mouse model Authors: Courtney Sutton1,2, Kaori Nozawa1,2, Katarzyna Kent1,2, Alexander Saltzman3, Mei Leng3, Sureshbabu Na...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-04-07 | MSV000091662 | MassIVE
TranscriptomicsElevated Lipoprotein(a) levels dictate a unique plaque phenotype and transcriptomic signature in transgenic mice with advanced atherosclerosis
We assessed the sex-specific effects of elevated Lp(a) on the development and progression of atherosclerosis in a humanized mouse model. Wild-type and mice with a humanized LPA gene were subject to CRISPR-mediated Ldlr knock out and 24 weeks of high-fat, high-cholesterol diet to induce atheroscleros...
ORGANISM(S): Mus musculus 
2026-09-17 | E-MTAB-17061 | biostudies-arrayexpress
GenomicsTumor cell-intrinsic Decr2 regulates ferroptosis and immunotherapy efficacy
Increased or decreased B16 cell sensitivity to activated cytotoxic T lymphocytes.To identify tumor cell-intrinsic genes essential for antigen-specific CD8+ T cell killing, we utilized the B16.SIY melanoma cell line which expressed the model antigen SIY (SIYRYYGL) co-expressed with DsRed, that can be...
ORGANISM(S): Mus musculus 
2025-06-30 | E-MTAB-13870 | biostudies-arrayexpress
UnknownErCas12a CRISPR-MAD7 for Model Generation in Human Cells, Mice, and Rats.
Not available
S-EPMC7194332 | biostudies-literature
UnknownGenerating Mouse Models Using CRISPR-Cas9-Mediated Genome Editing.
Not available
S-EPMC4848752 | biostudies-literature
GenomicsDevelopment and Characterization of a MPSIVA Mouse Model via CRISPR-Cas9 for Evaluating Novel Therapies Targeting Bone Disease
MPSIVA Mouse Model via CRISPR-Cas9 [WES]
PRJEB104948 | ENA
ProteomicsPhenotypic characterization of a Col6a3 knockout mouse model targeting exon 3
Mutations in COL6A3 lead to collagen VI-related myopathies due to COL6A3 loss. Therefore, studying the consequence of Col6a3 deregulated expression in mouse models is relevant, but the Col6a3 knockout mouse models currently available through a public repository does not entirely abolish COL6A3 prote...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-08 | PXD057310 | Pride
Mass spectrometry Muscular dystrophy Col6a3 Exon 3 Phenotype 
TranscriptomicsIn vivo CRISPR screen targeting TSGs in 185-3 MPNST cells
185-3 MPNST cells cells were screened with a CRISPR library against TSGs in vitro and as tumors in Rag1-null and immunocompetent WT C57BL/6 mice
ORGANISM(S): Mus musculus 
2021-10-01 | E-MTAB-10729 | biostudies-arrayexpress
GenomicsBreasi-CRISPR Ccnd2 Thr280Ala mutation E13.5-E15.5 embryonic mouse cortex with CRISPR silent controls
Breasi-CRISPR Ccnd2 Thr280Ala mutation E13.5-E15.5 embryonic mouse cortex with CRISPR silent controls
PRJNA1289856 | ENA
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