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MetabolomicsHost specific sphingomyelin is critical for replication of diverse RNA viruses
Lipids and lipid metabolism play an important role in RNA virus replication, which typically occurs on host cell endomembrane structures in the cytoplasm through mechanisms that are not yet fully identified. We conducted genome-scale CRISPR screening and identified sphingomyelin synthase 1 (SMS1; en...
2026-10-29 | MTBLS11308 | MetaboLights
TranscriptomicsTranscriptomic analysis reveals abnormal repair and remodeling in survivors of critical illness with sustained muscle weakness
ICU acquired weakness (ICUAW) is a complication of critical illness characterized by structural and functional impairment of skeletal muscle that may persist for years after ICU discharge with many survivors developing protracted courses with few regaining functional independence. Elucidating molec...
ORGANISM(S): Homo sapiens 
2016-07-18 | E-GEOD-78929 | biostudies-arrayexpress
TranscriptomicsInflammation-induced acute phase response in skeletal muscle and critical illness myopathy
Objectives: Systemic inflammation is a major risk factor for critical-illness myopathy (CIM) but its pathogenic role in muscle is uncertain. We observed that interleukin 6 (IL-6) and serum amyloid A1 (SAA1) expression was upregulated in muscle of critically ill patients. To test the relevance of the...
ORGANISM(S): Homo sapiens 
2014-05-06 | E-GEOD-53702 | biostudies-arrayexpress
TranscriptomicsHost gene expression profiling on children with any cause critical illness at retrieval or admission to paediatric critical care
We analysed data collected as part of the Biomarkers of Acute Serious Illness in Children (BASIC) study. BASIC was a prospective cohort study that enrolled critically ill children admitted to four PICUs in London and Eastern England, UK, during emergency transport by the Children’s Acute Transport S...
ORGANISM(S): Homo sapiens 
2025-09-30 | E-MTAB-15164 | biostudies-arrayexpress
TranscriptomicsCritical COPD respiratory illness is linked to increased transcriptomic activity of neutrophil proteases genes.
Abstract
BACKGROUND: Gene expression profiling (GEP) in cells obtained from peripheral blood has demonstrated to be a very useful approach for biomarker discovery and for studying molecular pathogenesis of prevalent diseases. While there is limited literature availble on gene expression markers a...
ORGANISM(S): Homo sapiens 
2013-03-12 | E-MEXP-3589 | biostudies-arrayexpress
UnknownAssociation between cholinesterase activity and critical illness brain dysfunction.
Not available
S-EPMC9724294 | biostudies-literature
UnknownThe epidemiology of chronic critical illness in the United States*.
Not available
S-EPMC7901538 | biostudies-literature
UnknownA Reflection on Current Definitions of Critical Care and Critical Illness-A Narrative Review of the Literature.
Not available
S-EPMC12781964 | biostudies-literature
UnknownCore outcomes sets for studies evaluating critical illness and patient recovery.
Not available
S-EPMC8314715 | biostudies-literature
UnknownPrevalence and Course of Frailty in Survivors of Critical Illness.
Not available
S-EPMC7941759 | biostudies-literature
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