Transcriptomic analysis reveals abnormal repair and remodeling in survivors of critical illness with sustained muscle weakness

ABSTRACT: ICU acquired weakness (ICUAW) is a complication of critical illness characterized by structural and functional impairment of skeletal muscle that may persist for years after ICU discharge with many survivors developing protracted courses with few regaining functional independence. Elucidating molecular mechanisms underscoring sustained ICUAW is crucial to understanding outcomes linked to different morbidity trajectories as well as for the development of novel therapies. Quadriceps muscle biopsies and functional measures of muscle strength and mass were obtained at 7 days and 6 months post-ICU discharge from a cohort of ICUAW patients. Unsupervised co-expression network analysis of transcriptomic profiles identified discrete modules of co-expressed genes associated with the degree of musc

ORGANISM(S): Homo sapiens

SUBMITTER: Claudia dos Santos 

PROVIDER: E-GEOD-78929 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress