Sort   by:  
 Page size 
TranscriptomicsMerlin/NF2 Suppresses Tumorigenesis by Inhibiting the E3 Ubiquitin Ligase CRL4DCAF1 in the Nucleus
Current models imply that the FERM domain protein Merlin, encoded by the tumor suppressor NF2, inhibits mitogenic signaling at or near the plasma membrane. Here, we show that the closed, growth inhibitory form of Merlin accumulates in the nucleus, binds to the E3 ubiquitin ligase CRL4DCAF1, and supp...
ORGANISM(S): Mus musculus 
2010-03-09 | E-GEOD-19305 | biostudies-arrayexpress
UnknownVprBP (DCAF1): a promiscuous substrate recognition subunit that incorporates into both RING-family CRL4 and HECT-family EDD/UBR5 E3 ubiquitin ligases.
Not available
S-EPMC3847654 | biostudies-literature
UnknownPlasmodium falciparum contains functional SCF and CRL4 ubiquitin E3 ligases, and CRL4 is critical for cell division and membrane integrity.
Not available
S-EPMC10927090 | biostudies-literature
ProteomicsProfiling Cullin4-E3 ligases interactomes and their rewiring in influenza A virus infection
Understanding the integrated regulation of cellular processes during viral infection is crucial for developing host-targeted approaches. We have previously reported that an optimal in-vitro infection by influenza A (IAV) requires three components of Cullin 4-RING E3 ubiquitin ligases (CRL4), namely ...
ORGANISM(S): Homo sapiens (Human) Influenza A virus (A/WSN/1933(H1N1)) 
2025-05-06 | PXD050261 | Pride
Human Ap-ms Q exactive plus Influenza virus 
UnknownMechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase.
Not available
S-EPMC3182024 | biostudies-literature
UnknownThe CARM1-p300-c-Myc-Max (CPCM) transcriptional complex regulates the expression of CUL4A/4B and affects the stability of CRL4 E3 ligases in colorectal cancer.
Not available
S-EPMC7053342 | biostudies-literature
UnknownProfiling Cullin4-E3 Ligases Interactomes and Their Rewiring in Influenza A Virus Infection.
Not available
S-EPMC11609542 | biostudies-literature
ProteomicsHormone-mediated disassembly and inactivation of a plant E3 ubiquitin ligase complex
Phytohormone abscisic acid (ABA) regulates key aspects of plant development such as seed germination, as well as responses to important environmental stresses, including drought, salinity and cold temperatures. The ABA signaling pathway is tightly controlled by the ubiquitin proteasome system. CULLI...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2024-09-11 | PXD055583 | Pride
Aba signaling Arabidopsis Csn Dda1 Plant proteostasis Csn5 inhibitor Pyr/pyl/rcar Aba receptor Pyl8 Crl4 e3 ligases 
ProteomicsHormone-mediated disassembly and inactivation of a plant E3 ubiquitin ligase complex_2nd dataset
Phytohormone abscisic acid (ABA) regulates key aspects of plant development such as seed germination, as well as responses to important environmental stresses, including drought, salinity and cold temperatures. The ABA signaling pathway is tightly controlled by the ubiquitin proteasome system. CULLI...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2024-09-11 | PXD055735 | Pride
Aba signaling Arabidopsis Csn Dda1 Plant proteostasis Csn5 inhibitor Pyr/pyl/rcar Aba receptor Pyl8 Crl4 e3 ligases 
UnknownAmyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.
Not available
S-EPMC5016122 | biostudies-literature
Sort   by:  
 Page size