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GenomicsmTORC1-Driven DDA1 Phosphorylation Promotes DNA Repair and Glioblastoma Progression
mTORC1-Driven DDA1 Phosphorylation Promotes DNA Repair and Glioblastoma Progression
PRJNA1293952 | ENA
TranscriptomicsmTORC1-Driven DDA1 Phosphorylation Promotes DNA Repair and Glioblastoma Progression
DDA1 is a protein involved in protein degradation, cell cycle regulation, and DNA damage repair. Interestingly, recent studies have revealed its differential expression across various tumor types. However, how DDA1 functions as a tumorogenic factor remains to be elucidated. Through studies in multip...
ORGANISM(S): Homo sapiens 
2025-07-29 | GSE303079 | GEO
ProteomicsDDA1, a novel factor in transcription-coupled repair, modulates CRL4CSA dynamics at DNA damage-stalled RNA polymerase II
Transcription-blocking DNA lesions are specifically targeted by transcription-coupled nucleotide excision repair (TC-NER), which removes a broad spectrum of DNA lesions to preserve transcriptional output and thereby cellular homeostasis to counteract aging. TC-NER is initiated by the stalling of RNA...
ORGANISM(S): Homo sapiens (Human) 
2024-05-02 | PXD051638 | Pride
Crl4csa Rna polymerase ii Dna damage Dda1 Transcription-coupled repair 
ProteomicsDDA1, a novel factor in transcription-coupled repair, modulates CRL4CSA dynamics at DNA damage-stalled RNA polymerase II
Transcription–blocking lesions are specifically targeted by transcription-coupled nucleotide excision repair (TC-NER), which removes a broad spectrum of DNA lesions to preserve transcriptional output and thereby cellular homeostasis to counteract aging. TC-NER is initiated by the physical stalling o...
ORGANISM(S): Homo sapiens (Human) 
2024-05-31 | PXD045415 | Pride
Dna damage-stalled rna polymerase ii Transcription-coupled repair Crl4csa dynamics Dda1 
UnknownDDA1, a novel oncogene, promotes lung cancer progression through regulation of cell cycle.
Not available
S-EPMC5542901 | biostudies-literature
UnknownMisregulation of the LOB domain gene DDA1 suggests possible functions in auxin signalling and photomorphogenesis.
Not available
S-EPMC2993911 | biostudies-literature
UnknownDDA1 promotes stage IIB-IIC colon cancer progression by activating NFκB/CSN2/GSK-3β signaling.
Not available
S-EPMC4991419 | biostudies-literature
UnknownThe small CRL4CSA ubiquitin ligase component DDA1 regulates transcription-coupled repair dynamics.
Not available
S-EPMC11286758 | biostudies-literature
UnknownDDA1, a novel factor in transcription-coupled repair, modulates CRL4CSA dynamics at DNA damage-stalled RNA polymerase II.
Not available
S-EPMC10602077 | biostudies-literature
ProteomicsCryo-EM structure of the human COP1-DET1 ubiquitin ligase complex
Ubiquitin modification regulates fundamental cellular processes by controlling protein stability and function. The ubiquitin ligase COP1, conserved from plants to humans, targets developmental transcription factors. COP1 can act on its own or be incorporated into CULLIN4–RING ligase (CRL4) complexes...
ORGANISM(S): Homo sapiens (Human) 
2026-01-23 | PXD071633 | Pride
Human Cop1-det1 ubiquitin ligase Cx-ms 
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