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Transcription profiling of liver from Csbm/m/Xpa-/- knockout mice to investigate the effect of nucleotide excision repair pathway inactivation

Cockayne syndrome (CS) is a photosensitive, DNA repair disorder associated with progeria caused by a defect in the transcription-coupled repair (TCR) subpathway of nucleotide excision repair (NER). Here, complete inactivation of NER in Csbm/m/Xpa-/- mutants causes a phenotype that reliably mimics th...

ORGANISM(S): Mus musculus

2007-01-01 | E-MEXP-835 | biostudies-arrayexpress

⁶⁸Ga-PSMA-PET/CT in addition to mpMRI in men undergoing biopsy during active surveillance for low- to intermediate-risk prostate cancer: study protocol for a prospective cross-sectional study.

Not available

S-EPMC10643393 | biostudies-literature

Ethical dilemmas in climate change and healthcare delivery: a cross-sectional survey of US patient perspectives.

Not available

S-EPMC12918491 | biostudies-literature

SPE-IMS-MS: An automated platform for sub-sixty second surveillance of endogenous metabolites and xenobiotics in biofluids

Characterization of endogenous metabolites and xenobiotics is essential to deconvoluting the genetic and environmental causes of disease. However, surveillance of chemical exposure and disease-related changes in large cohorts requires an analytical platform that offers rapid measurement, high sensit...

2017-02-14 | MTBLS427 | MetaboLights

A nuclear Argonaute promotes germline immortality and epigenetic inheritance across generations

dsRNA-mediated gene silencing (RNAi) can be inherited for multiple generations in C. elegans. To understand this process we conducted a genetic screen for animals defective for transmitting RNAi silencing signals to future generations. This screen identified the gene heritable RNAi defective (hrde)-...

ORGANISM(S): Caenorhabditis elegans

2012-07-30 | E-GEOD-38041 | biostudies-arrayexpress

Community-based HIV prevalence in KwaZulu-Natal, South Africa: results of a cross-sectional household survey.

Not available

S-EPMC7498647 | biostudies-literature

Severity of influenza-associated hospitalisations by influenza virus type and subtype in the USA, 2010-19: a repeated cross-sectional study.

Not available

S-EPMC10872935 | biostudies-literature

A developmental approach to diversifying neuroscience through effective mentorship practices: perspectives on cross-identity mentorship and a critical call to action.

Not available

S-EPMC9944572 | biostudies-literature

Phase II study of satraplatin and prednisone in patients with metastatic castration-resistant prostate cancer: a pharmacogenetic assessment of outcome and toxicity.