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ProteomicsDirect evidence of the presence of cross-linked Aβ dimers in the brains of Alzheimer’s disease patients
Brain-derived amyloid-β (Aβ) dimers are associated with Alzheimer´s disease (AD). However, their covalent nature remains controversial. This feature is relevant, as a covalent cross-link would make brain-derived dimers (native dimers) more synaptotoxic than Aβ monomers and would make them suitable c...
ORGANISM(S): Homo sapiens (Human) 
2021-05-13 | PXD005657 | Pride
Alzheimer’s disease Amyloid-β Oxidative stress Cross-linked dimers 
UnknownIdentification of neurotoxic cross-linked amyloid-β dimers in the Alzheimer's brain.
Not available
S-EPMC6487330 | biostudies-literature
UnknownTransforming Cross-Linked Cyclic Dimers of KR-12 into Stable and Potent Antimicrobial Drug Leads.
Not available
S-EPMC9953701 | biostudies-literature
ProteomicsLamin A molecular compression and sliding as mechanisms behind nucleoskeleton elasticity (complementary data of PXD008337)
Lamin A is a nuclear intermediate filament protein critical for nuclear architecture and mechanics and mutated in a wide range of human diseases. Yet little is known about the molecular architecture of lamins and mechanisms of their assembly. Here we use cross-linking SILAC mass spectrometry to dete...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-07-12 | PXD014009 | Pride
Lamin a Coiled coil Compression Disordered linker 
ProteomicsZNRF3 and RNF43 are active monomeric E3 ligases that self-associate
Crosslinking mass spectrometry was used to identify the site of dimerization in the RING domain of ZNRF3. The two proteins, ZNRF3 and RNF43 have a key role in regulating the number of Frizzled (FZD) receptor on cells and their inactivation causes cancer. This is because they are RING E3 ligases that...
ORGANISM(S): Homo sapiens (Human) 
2026-07-30 | PXD070424 | Pride
Znrf3 e3 ligase Cross-linking Ring dimerization 
ProteomicsIn vivo cross-linking supports a head-to-tail mechanism for regulation of the plant plasma membrane P-type H+-ATPase
In higher plants, a P-type proton pumping ATPase generates the proton-motive force essential for the function of all other transporters and for proper growth and development. X-ray crystallographic studies of the plant plasma membrane proton pump have provided information on amino acids involved in...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2018-09-24 | PXD010892 | Pride
And arabidopsis thaliana Mass spectrometry Protein cross-linking Protein-protein interaction H+-atpase 
UnknownAntiplasmodial Ealapasamines A-C,'Mixed' Naphthylisoquinoline Dimers from the Central African Liana Ancistrocladus ealaensis.
Not available
S-EPMC5515985 | biostudies-literature
UnknownDrug-Like Small Molecule HSP27 Functional Inhibitor Sensitizes Lung Cancer Cells to Gefitinib or Cisplatin by Inducing Altered Cross-Linked Hsp27 Dimers.
Not available
S-EPMC8145107 | biostudies-literature
UnknownEffect of base sequence on the DNA cross-linking properties of pyrrolobenzodiazepine (PBD) dimers.
Not available
S-EPMC3141243 | biostudies-literature
UnknownDi-tyrosine cross-link decreases the collisional cross-section of aβ peptide dimers and trimers in the gas phase: an ion mobility study.
Not available
S-EPMC4063900 | biostudies-literature
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