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UnknownStructural dynamics of the human COP9 signalosome revealed by cross-linking mass spectrometry and integrative modeling.
Not available
S-EPMC7049115 | biostudies-literature
ProteomicsMitochondrial protein interaction landscape of SS-31
SS-31 is a synthetic peptide that improves mitochondrial function and is currently undergoing clinical trials for treatments of heart failure, primary mitochondrial myopathy, and other mitochondrial diseases. SS-31 interacts with cardiolipin which is abundant in the inner mitochondrial membrane, but...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-12 | PXD019484 | Pride
Cross-linking mass spectometry Mitochondria Ss-31 Mouse Elamipretide 
ProteomicsThe molecular bases of spinal muscular atrophy
Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by the absence of a functional Survival of Motor Neuron 1 gene (SMN1). The nearly identical paralog, SMN2, cannot compensate for the loss of SMN1 because exon 7 is aberrantly skipped from most SMN2 transcripts, a process mediated by...
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD033055 | Pride
Biological sciences/molecular biology/rna metabolism/alternative splicing biological sciences/structural biology/x-ray crystallography health sciences/diseases/neurological disorders/motor neuron disease 
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