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MetabolomicsSS-31 and NMN: Two Paths to Improve Metabolism and Function in Aged Hearts
Not available
ORGANISM(S): Mus musculus 
ST001329 | MetabolomicsWorkbench
ProteomicsMitochondrial protein interaction landscape of SS-31
SS-31 is a synthetic peptide that improves mitochondrial function and is currently undergoing clinical trials for treatments of heart failure, primary mitochondrial myopathy, and other mitochondrial diseases. SS-31 interacts with cardiolipin which is abundant in the inner mitochondrial membrane, but...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-12 | PXD019484 | Pride
Cross-linking mass spectometry Mitochondria Ss-31 Mouse Elamipretide 
ProteomicsTargeting mitochondria in the aged vasculature with SS-31, a proteomic study of brain microvessels.
Functional decline and structural alterations of the brain microvasculature are associated with cognitive impairment and development of dementias such as Alzheimer’s disease during aging. Although mechanisms of leading to microvascular changes during aging are not clear, the loss of mitochondria and...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD038483 | Pride
Brain Tmt Mitochondria Microvessels 
ProteomicsMouse Heart SS-31 Proteome and Phosphoproteome
The heart proteome and phosphoproteome were analyzed in young (5-6-month old), old (24-month old at the start of the study), and elamipretide-treated (for 8 weeks) old mice using shotgun proteomics methods in order to assess the effects of aging on signaling and the ability of mitochondrion-targeted...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD026335 | Pride
Phosphoproteome Mouse Ss-31 Heart tissue Proteome Aging Elamipretide Lc-ms/ms 
TranscriptomicsSS-31 protects against paraquat-induced lung injury and fibrosis via inhibition of the MAPK signal pathway
Aims: To explore the therapeutic effect of SS-31 on lung injury and lung fibrosis caused by paraquat (PQ). Methods: In vivo experiments involved the intraperitoneal injection of PQ solution into C57BL/6 mice to induce lung injury and fibrosis. Subsequently, SS-31 solution was administered intraperit...
ORGANISM(S): Homo sapiens 
2026-03-15 | GSE261616 | GEO
GenomicsSS-31 Ameliorates DSS-Induced Colitis Through Mitochondrial Protection, Gene Regulation and Gut Microbiota Modulation
SS-31 Ameliorates DSS-Induced Colitis Through Mitochondrial Protection, Gene Regulation and Gut Microbiota Modulation
PRJNA1173574 | ENA
TranscriptomicsEffects of mitochondria-targeted antioxidant SS-31 on cigarette smoke-induced airway inflammation and oxidative stress in a mouse model
This study investigated whether mitochondria-targeted peptide SS-31 played a protective role in cigarette smoke (CS)-induced airway inflammation and oxidative stress in mice. Mice were exposed to CS for 4 weeks to establish a CS-induced airway inflammation model, then treated with SS-31. Pathologica...
ORGANISM(S): Mus musculus 
2020-12-25 | GSE163835 | GEO
GenomicsSS-31 protects against paraquat-induced lung injury and fibrosis via inhibition of the MAPK signal pathway
SS-31 protects against paraquat-induced lung injury and fibrosis via inhibition of the MAPK signal pathway
PRJNA1088117 | ENA
UnknownMitochondrial protein interaction landscape of SS-31.
Not available
S-EPMC7334473 | biostudies-literature
GenomicsEffects of mitochondria-targeted antioxidant SS-31 on cigarette smoke-induced airway inflammation and oxidative stress in a mouse model
Effects of mitochondria-targeted antioxidant SS-31 on cigarette smoke-induced airway inflammation and oxidative stress in a mouse model
PRJNA687734 | ENA
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