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ProteomicsBrain microvessels onotogeny-INSERM ERI28
Acquired neonatal brain lesions result from the co-incidence of environment deleterious factors occurring at a specific development stage. Hypoxia-ischemia and inflammation are the major triggers of brain damage in late pregnancy and early infancy, and result in a variety of damages depending on whe...
ORGANISM(S): Mus musculus (Mouse) 
2016-01-04 | PXD001718 | Pride
Neonate Mouse Ltq-orbitrap Brain Development Microvessels 
GenomicsGene expression profiling of the retinal microvessels and the brain microvessels
Gene expression profiling of the retinal microvessels and the brain microvessels
PRJNA434237 | ENA
TranscriptomicsDefining the Phosphodiesterase Superfamily Members in Rat Brain Microvessels
A filtration method followed by microarray analyses allows PDE components to be identified in brain microvessels, and confirmed that PDE4D and PDE5A are the primary forms expressed in rat brain microvessels. Adult male F344 rats were sacrificed and blocks of the cerebral cortex and infratentorial ar...
ORGANISM(S): Rattus norvegicus 
2012-02-01 | E-GEOD-35285 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of hypertensive and normotensive rats treated with the AT1 receptor antagonist candesartan and vehicle
In hypertension, abnormal regulation of microcirculation and endothelial dysfunction enhances vulnerability to hypertensive brain damage. In addition to lowering blood pressure, blockade of Angiotensin II AT1 receptors protects against stroke and stress in different animal models and this treatment ...
ORGANISM(S): Rattus norvegicus 
2007-11-03 | E-GEOD-2739 | biostudies-arrayexpress
ProteomicsTargeting mitochondria in the aged vasculature with SS-31, a proteomic study of brain microvessels.
Functional decline and structural alterations of the brain microvasculature are associated with cognitive impairment and development of dementias such as Alzheimer’s disease during aging. Although mechanisms of leading to microvascular changes during aging are not clear, the loss of mitochondria and...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD038483 | Pride
Brain Tmt Mitochondria Microvessels 
GenomicsStroke-induced transcriptomic alterations in mouse cerebral microvessels
Stroke-induced transcriptomic alterations in mouse cerebral microvessels
PRJNA914210 | ENA
TranscriptomicsGene expression profiling of the retinal microvessels and the brain microvessels
Rat retinal microvessels (RMVs) and brain microvessels (BMVs) were mechanically isolated under ice-cold condition. Retinal and brain tissues (RT, BT) from the same animals were collected for comparisons. Total RNA were individually extracted, amplified and processed on Affymetrix rat 2.0 microarray ...
ORGANISM(S): Rattus norvegicus 
2019-10-16 | GSE110675 | GEO
Transcriptomics3D vasculature-on-a-chip model of perfused human coronary artery endothelial microvessels for studying monocyte-to-endothelium adhesion in vitro: Use case application in systems toxicology
Lifestyle and genetic factors can lead to the development of atherosclerosis and, ultimately, cardiovascular adverse events. Rodent models are commonly used to investigate mechanism(s) of atherogenesis. However, the 3Rs principles, aiming to limit animal testing, encourage the scientific community t...
ORGANISM(S): Homo sapiens 
2019-08-27 | E-MTAB-7555 | biostudies-arrayexpress
TranscriptomicsStroke-induced transcriptomic alterations in mouse cerebral microvessels
To investigate the stroke-induced changes in gene expression in cerebral microvessels, we subjected mice to transient middle cerebral artery occlusion (tMCAO) or sham surgeries. 24h hours later, cerebral microvessels were harvested and RNA was isolated. We then performed gene expression profiling an...
ORGANISM(S): Mus musculus 
2022-12-24 | GSE221379 | GEO
GenomicsInflammatory response of 3D brain microvessels to TNF and Plasmodium falciparum
Inflammatory response of 3D brain microvessels to TNF and Plasmodium falciparum
PRJNA946310 | ENA
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