Sort   by:  
 Page size 
TranscriptomicsSequencing of HSV-1 genomic DNA to identify genomic variation resulting from selective pressure imposed by mutation of the PP1 binding site in the pUL21 gene
The pUL21 gene is essential for efficient replication and dissemination in herpes simplex virus 1 (HSV-1) but the molecular basis for its function is not well understood. Experimental work revealed that pUL21 is a virus-encoded adaptor of protein phosphatase 1 (PP1). Mutation of the specific motif i...
ORGANISM(S): Human alphaherpesvirus 1 
2021-07-31 | E-MTAB-10788 | biostudies-arrayexpress
TranscriptomicsWide-spread disruption of transcription termination in HSV-1 infection: Next generation sequencing of total and newly transcribed (4sU-RNA) RNA
Primary human foreskin fibroblasts (HFF) were infected with wild-type simplex virus 1 (HSV-1) strain 17 at a multiplicity of infection (MOI) of 10. Newly transcribed RNA was labelled by adding 500µM 4-thiouridine (4sU) to the cell culture media for 1h. Total cellular RNA was isolated using Trizol. N...
ORGANISM(S): Homo sapiens 
2015-05-26 | E-GEOD-59717 | biostudies-arrayexpress
TranscriptomicsWide-spread disruption of transcription termination in HSV-1 infection: Next-generation sequencing of translational activityd by ribosome profiling
Primary human foreskin fibroblasts (HFF) were infected with wild-type simplex virus 1 (HSV-1) strain 17 at a multiplicity of infection (MOI) of 10. Ribosome profiling was performed at various times during infection with minor modification to the protocol described in Stern-Ginossar N et al., Science...
ORGANISM(S): Homo sapiens 
2015-05-26 | E-GEOD-60040 | biostudies-arrayexpress
UnknownCOVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study.
Not available
S-EPMC8231091 | biostudies-literature
UnknownTen months of temporal variation in the clinical journey of hospitalised patients with COVID-19: An observational cohort.
Not available
S-EPMC8791638 | biostudies-literature
UnknownRespiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study.
Not available
S-EPMC9469080 | biostudies-literature
UnknownAssociation of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19.
Not available
S-EPMC10219675 | biostudies-literature
UnknownThrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry.
Not available
S-EPMC10439444 | biostudies-literature
UnknownImplementation of Recommendations on the Use of Corticosteroids in Severe COVID-19.
Not available
S-EPMC10751594 | biostudies-literature
UnknownThe value of open-source clinical science in pandemic response: lessons from ISARIC.
Not available
S-EPMC8489876 | biostudies-literature
Sort   by:  
 Page size