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ProteomicsSpatial tissue proteomics analysis of laser capture microdisscted intestinal crypt compartment
Crypt hyperplasia is a key feature of celiac disease and various other small intestinal inflammatory conditions. By undertaking mass spectrometry-based tissue proteomics of the gut epithelial crypt zone, we found that active celiac disease is characterized by a strong interferon-γ (IFN-γ) signal. Th...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-08 | PXD062684 | Pride
Mouse Intestine Interferon-gamma Crypt hyperplasia 
ProteomicsSpatial tissue proteomics analysis of laser capture microdisscted intestinal crypt compartment in celiac disease
Crypt hyperplasia is a key feature of celiac disease and various other small intestinal inflammatory conditions. By undertaking mass spectrometry-based tissue proteomics of the gut epithelial crypt zone, we found that active celiac disease is characterized by a strong interferon-γ (IFN-γ) signal. Th...
ORGANISM(S): Homo sapiens (Human) 
2025-08-08 | PXD062610 | Pride
Intestine Spatial proteomics Human Celiac disease 
UnknownIFN-γ is a direct driver of crypt hyperplasia in celiac disease.
Not available
S-EPMC12520675 | biostudies-literature
TranscriptomicsDietary heme mediated PPARM-NM-1 activation does not affect the heme-induced epithelial hyperproliferation and hyperplasia in mouse colon
Red meat consumption is associated with an increased colon cancer risk. Heme, present in red meat, injures the colon surface epithelium by luminal cytotoxicity and reactive oxygen species. This surface injury is overcompensated by hyperproliferation and hyperplasia of crypt cells. Transcriptome anal...
ORGANISM(S): Mus musculus 
2012-08-22 | E-GEOD-37006 | biostudies-arrayexpress
TranscriptomicsDietary heme stimulates epithelial cell turnover by downregulating feedback inhibitors of proliferation in murine colon (part 1)
The risk for colon cancer is associated with nutrition, especially with diets high in red meat. Red meat contains the iron porphyrin pigment heme, which induces cytotoxicity of the colon contents and epithelial hyperproliferation. Using a mouse model, we showed that heme caused damage to the colonic...
ORGANISM(S): Mus musculus 
2011-10-01 | E-GEOD-27847 | biostudies-arrayexpress
UnknownDistinct compartmentalization of NF-κB activity in crypt and crypt-denuded lamina propria precedes and accompanies hyperplasia and/or colitis following bacterial infection.
Not available
S-EPMC3264290 | biostudies-literature
UnknownCitrobacter rodentium lifA/efa1 is essential for colonic colonization and crypt cell hyperplasia in vivo.
Not available
S-EPMC1064951 | biostudies-literature
TranscriptomicsTranscription profiling of mouse intestinal cells expressing Lgr5 at high or low levels or with Ascl2 conditionally knocked out shows Ascl2 controls intestinal stem cell fate
The small intestinal epithelium is the most rapidly self-renewing tissue of mammals. Proliferative cells are confined to crypts, while differentiated cell types predominantly occupy the villi. We recently demonstrated the existence of a long-lived pool of cycling stem cells defined by Lgr5 expressio...
ORGANISM(S): Mus musculus 
2009-03-25 | E-GEOD-14201 | biostudies-arrayexpress
TranscriptomicsDietary heme stimulates epithelial cell turnover by downregulating feedback inhibitors of proliferation in murine colon (part 2)
The risk for colon cancer is associated with nutrition, especially high fat and low calcium diets high in red meat. Red meat contains the iron porphyrin pigment heme, which induces cytotoxicity of the colon contents and epithelial hyperproliferation. Using a mouse model, we showed that heme caused d...
ORGANISM(S): Mus musculus 
2011-10-01 | E-GEOD-27848 | biostudies-arrayexpress
TranscriptomicsDietary heme alters microbiota and mucosa of mouse colon without functional changes in host-microbe cross-talk.
Colon cancer is a major cause of cancer deaths in Western countries and is associated with diets high in red meat. Heme, the iron-porphyrin pigment of red meat, induces cytotoxicity of gut contents which injures surface cells leading to compensatory hyperproliferation of crypt cells. This hyperproli...
ORGANISM(S): Mus musculus 
2012-12-19 | E-GEOD-40672 | biostudies-arrayexpress
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