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TranscriptomicsTranscription profiling of human bronchial epithelial cells treated with interferon gamma and/or dexamethasone
RNA from cultured human bronchial epithelial cells treated for 8 hours or for 24 hours with medium alone, interferon gamma, dexamethasone or both interferon gamma and dexamethasone.
ORGANISM(S): Homo sapiens 
2007-08-25 | E-GEOD-1815 | biostudies-arrayexpress
TranscriptomicsInflammasome-dependent Interferon-gamma drives pathogenesis in Streptococcus pneumoniae meningitis.
A comparison of brain gene expression profiles in wildtype mice and interferon gamma -/- mice during bacterial meningitis.
ORGANISM(S): Mus musculus 
2012-09-01 | E-MEXP-3697 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of the response of human microglial cells to interferon gamma
Microglial cells are resident macrophages in the central nervous system (CNS) and play a pivotal role in the innate and adaptive immune responses against microbial infections. The immune functions of microglia are regulated by a milieu of cytokines including interferon (IFN)-gamma. We here performed...
ORGANISM(S): Homo sapiens 
2007-08-03 | E-GEOD-1432 | biostudies-arrayexpress
TranscriptomicsRole of CDK8 in interferon-gamma-induced gene expression
Gene regulation by cytokine-activated STAT transcription factors requires serine phosphorylation within the transactivation domain (TAD). STAT1 and STAT3 TAD phosphorylation was reported to occur upon promoter binding by an unknown kinase. Here we show that the Mediator CDK8 module phosphorylates S7...
ORGANISM(S): Mus musculus 
2013-02-28 | E-GEOD-40728 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human macrophages from ankylosing spondylitis patients reveals interferon-gamma dysregulation
OBJECTIVE: To determine whether macrophages, a type of cell implicated in the pathogenesis of ankylosing spondylitis (AS), exhibit a characteristic gene expression pattern. METHODS: Macrophages were derived from the peripheral blood of 8 AS patients (median disease duration 13 years [range <1-43 yea...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-11886 | biostudies-arrayexpress
GenomicsConserved interferon-gamma signaling and decreased immune exclusion programs in responses to immune checkpoint blockade therapy
We analyzed baseline and on-therapy tumor biopsies from 101 patients with advanced melanoma treated with nivolumab (anti-PD-1) alone or combined with ipilimumab (anti-CTLA-4). Analysis of whole transcriptome data showed that T cell infiltration and interferon-gamma signaling signatures corresponded ...
EGAS00001004545 | EGA
TranscriptomicsRNA-seq of mouse intestinal organoids treated with interferon-gamma
We aimed to investigate gene expression changes in intestinal organoids from different mouse genotypes after treatment with interferon-gamma. Wild-type, villinCreER;KrasG12D/+;Trp53fl/flRosa26N1icd/+ (KPN), and villinCreER;Apcfl/fl;KrasG12D/+;Trp53fl/flTgfbrIfl/fl (AKPT) intestinal organoids were pl...
ORGANISM(S): Mus musculus 
2022-06-30 | E-MTAB-11769 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of neonatal rat microglia after IFN-gamma activation
IFN-gamma is a classical microglial stimulant. We used microarrays to investigate the microglial gene regulatory network activated by interferon-gamma. Experiment Overall Design: Primary rat microglia cultures were established and maintained for 15 days. For activation studies, fresh media containi...
ORGANISM(S): Rattus norvegicus 
2008-06-14 | E-GEOD-6353 | biostudies-arrayexpress
TranscriptomicsInterferon-gamma Induced Gene Expression Changes in Human Neutrophils
The cytokine interferon-gamma (IFN-gamma) is used as a drug to treat Chronic Granulomatous Disease (CGD), a group of genetic disorders characterized by defects in components of the neutrophil-resident NADPH oxidase/Nox2 enzyme system. Administration of IFN-gamma to these patients results in decreas...
ORGANISM(S): Homo sapiens 
2018-12-14 | E-MTAB-7261 | biostudies-arrayexpress
TranscriptomicsExpression via microarray of total RNA isolated from B16 murine melanoma cells stimulated with Interferon-gamma versus untreated controls.
Functional in vitro studies revealed changes in B16 melanoma migration and proliferation when exposed to Interferon-gamma.
ORGANISM(S): Mus musculus 
2019-01-31 | E-MTAB-6372 | biostudies-arrayexpress
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