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TranscriptomicsExpression data from human glioma cancer stem cell (CSC) specimens following knockdown of GREM1
CSCs differentially secrete the BMP antagonist Gremlin1 compared to non-stem glioma populations. Knockdown of Gremlin1 decreases CSC proliferation and tumorigenicity, establishing Gremlin1 as an essential effector for CSC maintenance. We used a microarray to determine the gene expression programs t...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-52846 | biostudies-arrayexpress
TranscriptomicsSABiosciences Human miRNA PCR array assay of normal respiratory epithelia and lung cancer cells with or without treatment of CSC
MicroRNAs are critical mediators of stem cell pluripotency, differentiation and malignancy. Limited information exists regarding microRNA alterations that facilitate initiation and progression of human lung cancers. In this study, array techniques were used to evaluate microRNA expression in norma...
ORGANISM(S): Homo sapiens 
2012-12-18 | E-GEOD-42962 | biostudies-arrayexpress
TranscriptomicsPNAs-A15 effects on non-small cell lung cancer cell line
Expression profile of parental wild type non-small cell lung cancer, NCI-H460, and cancer stem cell-rich (CSC-rich) populations treated with PNAs-A15 for 6 h. Results provide the information that PNAs-A15, a peptide nucleic acid of A-repeats length 15 bp, suppressed up-regulated A-repeats containing...
ORGANISM(S): Homo sapiens 
2016-03-17 | E-GEOD-79308 | biostudies-arrayexpress
TranscriptomicsGene expression in colon cancer stem cells (CSC) cultures identified by Wnt signaling levels
Primary colon CSC cultures were transduced with a Wnt responsive construct (TOP-GFP) and were single cell cloned. 10% highest and lowest TOP-GFP cell fractions were FACS sorted and arrayed. Primary colon CSC cultures with a responsive construct (TOP-GFP): high and low TOP-GFP cell fractions. 4 sampl...
ORGANISM(S): Homo sapiens 
2009-12-01 | E-GEOD-17375 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human bronchial epithelial cells to low doses of cigarette smoke condensate - chronic exposure
BEAS-2B cells have been treated with low doses (20 ug/ml) of CSC for 4 months. As negative control BEAS-2B cells were treated with DMSO (the CSC solvent). Non-treated cells were cultivated in parallel. Experiment Overall Design: After each month total RNA was extracted from three replicates of CSC, ...
ORGANISM(S): Homo sapiens 
2009-08-09 | E-GEOD-14383 | biostudies-arrayexpress
GenomicsExpression data from CSC and Non-CSC of three primary HCC samples
Expression data from CSC and Non-CSC of three primary HCC samples
PRJNA505166 | ENA
ProteomicsExosomes from GBM established cell lines (U87, U373) and GBM primary CSC
In this study, we investigated and compared the miRNA and protein content of the small EVs released by different human GBM established cell lines and by GBM primary CSC lines, to explore the role of EVs in their different tumor behavior and capacities.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-01-11 | MSV000088671 | MassIVE
GenomicsGenome-wide analysis of gene expression by IFNβ in Transformed HMEC (Epithelial/non-CSC, Mesenchymal/CSC)
Genome-wide analysis of gene expression by IFNβ in Transformed HMEC (Epithelial/non-CSC, Mesenchymal/CSC)
PRJNA418007 | ENA
TranscriptomicsExpression data from CSC and Non-CSC of three HCC cell lines
Hepatocellular carcinoma (HCC) represents the major subtype of liver cancer, characterized with a high rate of recurrence and heterogeneity. Liver cancer stem cells (CSCs) may account for a hierarchical organization of heterogeneous cancer cells. However, how liver CSCs sustain their self-renewal re...
ORGANISM(S): Homo sapiens 
2015-03-05 | E-GEOD-66529 | biostudies-arrayexpress
GenomicsTranscriptome analysis of mesenchymal CSC-like cells harboring mutant p53
Transcriptome analysis of mesenchymal CSC-like cells harboring mutant p53
PRJNA484761 | ENA
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