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TranscriptomicsCSF-1R inhibition alters macrophage polarization and blocks gliomagenesis
Glioblastoma multiforme (GBM), the most common and aggressive primary brain tumor in adults, can be divided into several molecular subtypes including proneural GBM. Most clinical strategies aimed at directly targeting glioma cells in these tumors have failed. A promising alternative is to target str...
ORGANISM(S): Mus musculus 
2013-09-20 | E-GEOD-37475 | biostudies-arrayexpress
ProteomicsCSF-1R regulates metal ion homeostasis in the brain – implications for neurodegenerative disease
Dominant inactivating mutations in the colony stimulating factor-1 receptor (CSF1R) cause an adult-onset neurodegenerative disease associated with white matter loss and axonal degeneration designated CSF-1R related leukoencephalopathy (CRL), that is modeled in the Csf1r+/- mouse. CRL is caused by mi...
ORGANISM(S): Homo sapiens (Human) 
2026-02-18 | PXD067561 | Pride
Microglia dysfunction Oligodendrocyte stress Metallothionein mt1 Metal ion homeostasis Metallothionein mt3 Csf-1r signaling Csf1r-related leukoencephalopathy Mitochondrial dysfunction Ros Oxidative stress Neurodegeneration Single-nucleus rna sequencing 
UnknownCSF-1R regulates non-small cell lung cancer cells dissemination through Wnt3a signaling.
Not available
S-EPMC5714744 | biostudies-literature
UnknownTiming of CSF-1/CSF-1R signaling blockade is critical to improving responses to CTLA-4 based immunotherapy.
Not available
S-EPMC5006914 | biostudies-literature
UnknownThe mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1.
Not available
S-EPMC3372767 | biostudies-literature
GenomicsDisruption of CSF-1R signaling affects cerebellar and forebrain homeostasis
Disruption of CSF-1R signaling affects cerebellar and forebrain homeostasis
PRJNA551259 | ENA
TranscriptomicsA  paracrine IGF1/IGF1R-PI3K signaling loop underlies resistance to CSF-1R inhibition in GBM
Glioblastoma multiforme (GBM) is the most aggressive form of glioma, and is notorious for its terminal prognosis and lack of responsiveness to current treatment approaches. The brain tumor microenvironment (TME) represents a largely untapped reservoir of therapeutic target options in GBM. Here we ha...
ORGANISM(S): Mus musculus 
2016-05-20 | GSE69104 | GEO
UnknownProfiling Y561-dependent and -independent substrates of CSF-1R in epithelial cells.
Not available
S-EPMC2964295 | biostudies-literature
UnknownPrognostic Significance of CSF-1R Expression in Early Invasive Breast Cancer.
Not available
S-EPMC8616299 | biostudies-literature
UnknownDelivery of CSF-1R to the lumen of macropinosomes promotes its destruction in macrophages.
Not available
S-EPMC4265739 | biostudies-literature
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