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TranscriptomicsTHOC5, a member of the mRNA export complex, is essential for hematopoiesis in vivo and is required for CSF-1 induced macrophage differentiation
THOC5, a member of the mRNA export complex, is essential for hematopoiesis in vivo and is required for CSF-1 induced macrophage differentiation, thereby playing a key role in the mRNA export of immediate early genes induced by CSF-1 stimulation. Hematopoiesis, growth, differentiation, and commitment...
ORGANISM(S): Mus musculus 
2013-12-24 | E-GEOD-41170 | biostudies-arrayexpress
TranscriptomicsHuman monocyte-derived macrophages polarized by GM-CSF or M-CSF
Identification of genes differentially expressed between human monocyte-macrophages generated in the presence of either GM-CSF (termed M1) or M-CSF (termed M2) Human peripheral blood monocytes from three independent healthy donors (#1, #2 and #3) were isolated by anti-CD14-labeled magnetic microbead...
ORGANISM(S): Homo sapiens 
2012-04-12 | E-GEOD-27792 | biostudies-arrayexpress
TranscriptomicsMultiple sclerosis patient-derived CSF induces transcriptional changes in proliferating oligodendrocyte progenitors
This study provides an overview of the transcriptional signature of oligodendrocyte progenitor cells (OPCs) exposed to the CSF collected from multiple sclerosis patients with either a relapsing remitting disease course (RRMS) or a confirmed primary progressive diagnosis (PPMS). Using an Affymetrix ...
ORGANISM(S): Rattus norvegicus 
2015-06-19 | E-GEOD-60881 | biostudies-arrayexpress
TranscriptomicsHematopoietic stem cells from mice treated with G-CSF or saline alone for 36 hours
Recent studies demonstrate that inflammatory signals regulate hematopoietic stem cells (HSCs). Granulocyte-colony stimulating factor (G-CSF) is often induced with infection and plays a key role in the stress granulopoiesis response. However, its effects on HSCs are less clear. Herein, we show tha...
ORGANISM(S): Mus musculus 
2014-02-19 | E-GEOD-55093 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse wild type and Stat5a or 5b knock-out blood cells treated with GM-CSF to induce granulopoiesis
GM-CSF controls the development of granulocytes but little is known about the contribution of the downstream mediating transcription factor STAT5A/B. To elucidate this pathway, we generated mice lacking the Stat5a and 5b genes in blood cells. Peripheral neutrophils were decreased and administratio...
ORGANISM(S): Mus musculus 
2009-10-10 | E-GEOD-14672 | biostudies-arrayexpress
GenomicsChIP-seq of CSF-1R, H3K4me1, H3K4me3 in human primary unstimulated monocytes and monocytes differentiated 72h with CSF-1 (3 healthy donors buffy coat) and in monocytes from two CMML patients and one healthy donor, EGR1 ChIP-seq in unstimulated monocytes (3 healthy donors buffy coat)
Identification of nuclear CSF-1R, H3K4me1 and H3K4me3 localization on chromatin in human primary monocytes and modification of this localization during monocyte differentiation into macrophage induced by 100ng/mL CSF-1 during 6 hours (1 donor) or 72h (3 donors). Identification of EGR1 chromatin loc...
ORGANISM(S): Homo sapiens 
2019-03-04 | E-MTAB-6305 | biostudies-arrayexpress
MetabolomicsMetabolomic profiling of cerebrospinal fluid from dogs with meningoencephalitis of unknown origin by nuclear magnetic resonance

Introduction: Meningoencephalitis of unknown origin (MUO) in dogs is a very debilitating and potentially fatal disease that is a potential model for multiple sclerosis in humans. The metabolomic profile of MUO has not been previously reported.

Objectives: To describe the metabolomic profile...

2026-03-05 | MTBLS6053 | MetaboLights
TranscriptomicsHuman Monocytes to M-CSF differentiated Macrophages
This dataset was created to study M-CSF dependent in vitro differentiation of human monocytes to macrophages as a model process to demonstrate that independent component analysis (ICA) is a useful tool to support and extend knowledge-based strategies and to identify complex regulatory networks or no...
ORGANISM(S): Homo sapiens 
2011-11-07 | E-GEOD-9801 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human PMNs to compare global gene expression in human neutrophils during spontaneous apoptosis with that in cells cultured with human GM-CSF
PMNs were isolated from venous blood of healthy individuals in accordance with a protocol approved by the Institutional Review Board for Human Subjects, National Institute of Allergy and Infectious Diseases. Human PMNs (107) were cultured in RPMI/H -/+ 100 ng/ml GM-CSF at 37°C and 5% CO2 for up to ...
ORGANISM(S): Homo sapiens 
2007-09-20 | E-GEOD-2803 | biostudies-arrayexpress
TranscriptomicsAMD3100 and G-CSF Mobilize Different CD34+ Cell Populations Based on Gene and miRNA Expression
Plerixafor (AMD3100) and G-CSF mobilize peripheral blood stem cells (PBSCs) by different mechanisms. A rhesus macaque model was used to compare plerixafor and G-CSF-mobilized CD34+ cells. Three PBSC concentrates were collected from 3 macaques treated with G-CSF, plerixafor, or plerixafor plus G-CSF....
ORGANISM(S): Macaca mulatta 
2009-12-04 | E-GEOD-16936 | biostudies-arrayexpress
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