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TranscriptomicsComparison of young and aged F344 rat coronary artery
Previous studies showed that aging in coronary arteries is associated with pro-inflammatory phenotypic changes and decreased NO bioavailability, which, we hypothesized, promotes vascular disease by inducing endothelial apoptosis. To test this hypothesis we characterized pro-apoptotic alterations in ...
ORGANISM(S): Rattus norvegicus 
2010-06-05 | E-GEOD-619 | biostudies-arrayexpress
UnknownIGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis.
Not available
S-EPMC5061677 | biostudies-literature
UnknownOld blood from heterochronic parabionts accelerates vascular aging in young mice: transcriptomic signature of pathologic smooth muscle remodeling.
Not available
S-EPMC9135944 | biostudies-literature
TranscriptomicsTranscription profiling of mouse left ventricle from male (-/-) (n=3) and (+/+) (n=4) at the age of 21M to do exercise and transcriptional analysis in male eNOS Knockout Mice
There is cardiac dysfunction in male eNOS (-/-) with age and 50% mortality at 21M. It was of interest to investigate the gene expression profile of aged eNOS (-/-) male in comparison to (+/+) in order to explore the genetic markers and molecular mechanisms leading to heart failure. RNA was extracted...
ORGANISM(S): Mus musculus 
2007-11-06 | E-GEOD-1988 | biostudies-arrayexpress
TranscriptomicsResveratrol Diet Aging (Heart, Liver, Muscle and Fat Tissue)
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending lifespan A small molecule that safely mimics the ability of dietary restriction (DR) to delay age-related diseases in laboratory animals is greatly sought after. We and others ha...
ORGANISM(S): Mus musculus 
2008-08-04 | E-GEOD-11845 | biostudies-arrayexpress
TranscriptomicsSRT1720 extends healthspan and lifespan in diet-induced obese mice
Activation of Sirt1, the mammalian homolog of an NAD+-dependent deacetylase known to modulate lifespan in lower organisms, is thought to hold promise as a strategy for delaying aging in mammals. SRT1720, a novel compound developed as a specific and potent activator of Sirt1, has shown promising effe...
ORGANISM(S): Mus musculus 
2011-08-17 | E-GEOD-19102 | biostudies-arrayexpress
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