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ProteomicsApoA-I [human] (CSL112) infusion increases LCAT levels in HDL particles and promotes reverse cholesterol transport
Background: High-density lipoprotein (HDL)-cholesterol is inversely correlated with cardiovascular risk, but increasing its circulating concentration is insufficient to prevent adverse cardiovascular outcomes. Instead, the emerging paradigm is on increasing the function of HDL and its major protein...
ORGANISM(S): Homo sapiens (Human) 
2025-06-16 | PXD057196 | Pride
Lecithin-cholesterol acyl transferase Proteome Csl112 High-density lipoprotein Acute myocardial infarction 
UnknownClinical Pharmacokinetics and Pharmacodynamics of CSL112.
Not available
S-EPMC10019422 | biostudies-literature
UnknownApolipoprotein A1 (CSL112) Increases Lecithin-Cholesterol Acyltransferase Levels in HDL Particles and Promotes Reverse Cholesterol Transport.
Not available
S-EPMC12134602 | biostudies-literature
UnknownPharmacokinetics and Safety of CSL112 (Apolipoprotein A-I [Human]) in Adults With Moderate Renal Impairment and Normal Renal Function.
Not available
S-EPMC6618313 | biostudies-literature
UnknownModerate Renal Impairment Does Not Impact the Ability of CSL112 (Apolipoprotein A-I [Human]) to Enhance Cholesterol Efflux Capacity.
Not available
S-EPMC6587782 | biostudies-literature
UnknownEffect of CSL112 (apolipoprotein A-I [human]) on cholesterol efflux capacity in Japanese subjects: Findings from a phase I study and a cross-study comparison.
Not available
S-EPMC9579388 | biostudies-literature
UnknownCSL112 (Apolipoprotein A-I [Human]) Enhances Cholesterol Efflux Similarly in Healthy Individuals and Stable Atherosclerotic Disease Patients.
Not available
S-EPMC5895137 | biostudies-literature
UnknownEvaluation of potential antiplatelet effects of CSL112 (Apolipoprotein A-I [Human]) in patients with atherosclerosis: results from a phase 2a study.
Not available
S-EPMC5889770 | biostudies-literature
UnknownInfusion of Reconstituted High-Density Lipoprotein, CSL112, in Patients With Atherosclerosis: Safety and Pharmacokinetic Results From a Phase 2a Randomized Clinical Trial.
Not available
S-EPMC4599471 | biostudies-literature
UnknownEnhanced HDL Functionality in Small HDL Species Produced Upon Remodeling of HDL by Reconstituted HDL, CSL112: Effects on Cholesterol Efflux, Anti-Inflammatory and Antioxidative Activity.
Not available
S-EPMC5006797 | biostudies-literature
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