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TranscriptomicsTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
RNA-seq analysis on neurospheres derived from wt and Cstb-knockout mouse embryo brains before differentiation and during differentiation at days 1, 5, and 12.
ORGANISM(S): Mus musculus 
2021-12-31 | E-MTAB-8934 | biostudies-arrayexpress
TranscriptomicsGene expression data of cultured primary microglia from neonatal control and Cstb-/- mice.
Cystain B (Cstb) is a ubiquitously expressed cysteine protease inhibitor and mutations of the CSTB gene lead to the neurodegenerative disease progressive myoclonus epilepsy of Unverricht-Lundorg type (EPM1). We are interested in the microglia-specific, Cstb-dependent gene-expression changes in mice ...
ORGANISM(S): Mus musculus 
2016-06-29 | E-GEOD-64823 | biostudies-arrayexpress
TranscriptomicsGene expression alterations in the cerebellum and granule neurons of Cstb-/- mouse are associated with early synaptic changes and inflammation
Progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1) is an inherited neurodegenerative disease with myoclonus, seizures and ataxia, caused by the mutations in cystatin B (CSTB) gene. In an approach towards understanding the molecular basis of pathogenic events in EPM1 we have utilized t...
ORGANISM(S): Mus musculus 
2014-03-03 | E-GEOD-47516 | biostudies-arrayexpress
GenomicsTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Transcriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
PRJEB37759 | ENA
UnknownThe effects of Cstb duplication on APP/amyloid-β pathology and cathepsin B activity in a mouse model.
Not available
S-EPMC8297773 | biostudies-literature
UnknownIn depth behavioral phenotyping unravels complex motor disturbances in Cstb-/- mouse, a model for progressive myoclonus epilepsy type 1.
Not available
S-EPMC10764494 | biostudies-literature
TranscriptomicsGene expression alterations in the cerebellum and granule neurons of Cstb-/- mouse are associated with early synaptic changes and inflammation
Progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1) is an inherited neurodegenerative disease with myoclonus, seizures and ataxia, caused by the mutations in cystatin B (CSTB) gene. In an approach towards understanding the molecular basis of pathogenic events in EPM1 we have utilized t...
ORGANISM(S): Mus musculus 
2014-03-03 | GSE47516 | GEO
UnknownGene-Expression Profiling Suggests Impaired Signaling via the Interferon Pathway in Cstb-/- Microglia.
Not available
S-EPMC4927094 | biostudies-literature
UnknownGene expression alterations in the cerebellum and granule neurons of Cstb(-/-) mouse are associated with early synaptic changes and inflammation.
Not available
S-EPMC3937333 | biostudies-literature
UnknownBrain inflammation is accompanied by peripheral inflammation in Cstb -/- mice, a model for progressive myoclonus epilepsy.
Not available
S-EPMC5127053 | biostudies-literature
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