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ProteomicsAntigen presentation deficiency, mesenchymal differentiation, and resistance to immunotherapy in the murine syngeneic CT2A tumor model
A common cornerstone of preclinical cancer research is the use of syngeneic orthotopic murine tumors as immunocompetent models of human cancers. For glioblastoma research efforts, the GL261 and CT2A lines are frequently used. We systematically characterized these two lines to decipher the cell-intr...
ORGANISM(S): Mus musculus (Mouse) 
2023-12-19 | PXD036720 | Pride
Ct2a Glioblastoma Immunotherapy Gl261 
GenomicsEffects of the treatment with IFNβ and GM-CSF-secreting CT2A cells to wildtype CT2A tumor microenvironment post resection
Effects of the treatment with IFNβ and GM-CSF-secreting CT2A cells to wildtype CT2A tumor microenvironment post resection
PRJNA898299 | ENA
TranscriptomicsEffects of the treatment with IFNβ and GM-CSF-secreting CT2A cells to wildtype CT2A tumor microenvironment post resection
To elucidate the underlying immune responses elicited by IFNβ and GM-CSF-secreting CT2A cells to brain tumor microenvironment post resection compared to placebo group and non-IFNβ and GM-CSF-secreting CT2A cell group
ORGANISM(S): Mus musculus 
2022-11-09 | GSE217253 | GEO
UnknownAntigen presentation deficiency, mesenchymal differentiation, and resistance to immunotherapy in the murine syngeneic CT2A tumor model.
Not available
S-EPMC10782385 | biostudies-literature
GenomicsTranscriptional analysis of ATRX deficiency in a CT2A glioma model
Transcriptional analysis of ATRX deficiency in a CT2A glioma model
PRJNA949116 | ENA
GenomicsEffect of inhibition of LDHA using FX11 on gene expression in CT2A glioma cells
Effect of inhibition of LDHA using FX11 on gene expression in CT2A glioma cells
PRJNA892026 | ENA
TranscriptomicsEffect of inhibition of LDHA using FX11 on gene expression in CT2A glioma cells
To investigate the role of LDHA in regulating gene expression in glioma cells, we treated CT2A glioma cells with LDHA inhibitor FX11. We then performed gene expression profiling analysis using data obtained from RNA-seq of control and FX11-treated cells.
ORGANISM(S): Mus musculus 
2023-11-09 | GSE216070 | GEO
GenomicsRNAseq of tumor endothelial cells isolated from CT2A glioma under control or LGK974 treatment
RNAseq of tumor endothelial cells isolated from CT2A glioma under control or LGK974 treatment
PRJNA839710 | ENA
GenomicsCD169 is a marker of IFN-γ-stimulated inflammatory macrophages in brain tumor [CT2A]
CD169 is a marker of IFN-γ-stimulated inflammatory macrophages in brain tumor [CT2A]
PRJNA832218 | ENA
GenomicsTranscriptional analysis of co-occuring ATRX deficiency and IDH1 mutation in a CT2A glioma model
Transcriptional analysis of co-occuring ATRX deficiency and IDH1 mutation in a CT2A glioma model
PRJNA948443 | ENA
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