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TranscriptomicsFanconi anemia proteins interact with CtBP1 and modulate the expression of the Wnt antagonist Dickkopf-1
Fanconi anemia (FA) is a genetic disorder characterized by congenital abnormalities, bone marrow failure and increased susceptibility to cancer. Of the fifteen FA proteins, Fanconi anemia group C (FANCC) is one of eight FA core complex components of the FA pathway. Unlike other FA core complex prote...
ORGANISM(S): Homo sapiens 
2013-04-05 | E-GEOD-43330 | biostudies-arrayexpress
ProteomicsA pathogenic CtBP1 missense mutation causes altered cofactor binding and transcriptional activity
We previously reported a pathogenic de novo W342 mutation in the transcriptional corepressor CtBP1 in four independent patients with neurodevelopmental disabilities. Here, we report the clinical phenotypes of seven additional individuals with the same recurrent de novo CtBP1 mutation. Within this ...
ORGANISM(S): Homo sapiens (Human) 
2019-05-09 | PXD012702 | Pride
Human Ctbp1 Proteomics 
TranscriptomicsEffect of CtBP1 knockdown in SCC25 cells
Cells were transfected with siRNA targetting CtBP1, or a non-targetting control siRNA. mRNA was extracted for gene expression analysis 48 hours after transfection
ORGANISM(S): Homo sapiens 
2017-02-03 | E-MTAB-3295 | biostudies-arrayexpress
TranscriptomicsEffects of PSF and CTBP1-AS knockdown in prostate cancer cell lines
Prostate cancer is the most common cancer in men and Androgen receptor (AR) downstream signalings promote prostate cancer cell proliferation. We identified androgen-regulated long non-coding RNA, CTBP1-AS, located in the antisese region of CTBP1 gene. CTBP1-AS activate AR signaling by epigeneticall...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-GEOD-44264 | biostudies-arrayexpress
GenomicsThe whole transcriptome expression profiling of human SKOV3 comparison between control and CtBP1 KD, ctbp2 KD and CTBP1/2 DKD.
The whole transcriptome expression profiling of human SKOV3 comparison between control and CtBP1 KD, ctbp2 KD and CTBP1/2 DKD.
PRJNA732376 | ENA
GenomicsA pathogenic CtBP1 missense mutation causes altered cofactor binding and transcriptional activity
A pathogenic CtBP1 missense mutation causes altered cofactor binding and transcriptional activity
PRJNA521403 | ENA
GenomicsIsogenic Wild Type and iPSC-Derived CTBP1 Mutant Neuronal Cells Exhibit Neurodevelopmental Defects
Isogenic Wild Type and iPSC-Derived CTBP1 Mutant Neuronal Cells Exhibit Neurodevelopmental Defects
PRJNA1309128 | ENA
TranscriptomicsThe whole transcriptome expression profiling of human SKOV3 comparison between control and CtBP1 KD, ctbp2 KD and CTBP1/2 DKD.
To discover the regulatory role of CTBP1/2 in high grade serous ovarian cancer, The full cDNA was extracted from SKOV3 shRNA control and CtBP1/2 knockdown and then compared the expression profiles of them to discovery the key functions and pathways regulated by CtBP1/2..
ORGANISM(S): Homo sapiens 
2022-05-21 | GSE175425 | GEO
UnknownCtBP1 overexpression in keratinocytes perturbs skin homeostasis.
Not available
S-EPMC4537778 | biostudies-literature
GenomicsExpression data of PRDM14 overexpression in WT, Suz12 KO and Ctbp1/2 DKO ESCs
Expression data of PRDM14 overexpression in WT, Suz12 KO and Ctbp1/2 DKO ESCs
PRJNA556017 | ENA
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