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GenomicsCRISPR-mediated deletion of prostate cancer risk-associated CTCF loop anchors identifies repressive chromatin loops
CRISPR-mediated deletion of prostate cancer risk-associated CTCF loop anchors identifies repressive chromatin loops
PRJNA485892 | ENA
UnknownG-quadruplexes associated with R-loops promote CTCF binding.
Not available
S-EPMC10529333 | biostudies-literature
UnknownCRISPR-mediated deletion of prostate cancer risk-associated CTCF loop anchors identifies repressive chromatin loops.
Not available
S-EPMC6176514 | biostudies-literature
TranscriptomicsCohesin is a key determinant of interphase chromosome domain architecture (HiC)
To ensure proper gene regulation within constrained nuclear space, chromosomes facilitate access to transcribed regions, while compactly packaging all other information. Recent studies revealed that chromosomes are organized into megabase-scale domains that demarcate active and inactive genetic elem...
ORGANISM(S): Mus musculus 
2013-12-11 | E-GEOD-49017 | biostudies-arrayexpress
TranscriptomicsCohesin is a key determinant of interphase chromosome domain architecture (RNA-seq)
To ensure proper gene regulation within constrained nuclear space, chromosomes facilitate access to transcribed regions, while compactly packaging all other information. Recent studies revealed that chromosomes are organized into megabase-scale domains that demarcate active and inactive genetic elem...
ORGANISM(S): Mus musculus 
2013-12-11 | E-GEOD-48965 | biostudies-arrayexpress
GenomicsCohesin is a key determinant of interphase chromosome domain architecture (ChIP-seq)
To ensure proper gene regulation within constrained nuclear space, chromosomes facilitate access to transcribed regions, while compactly packaging all other information. Recent studies revealed that chromosomes are organized into megabase-scale domains that demarcate active and inactive genetic elem...
ORGANISM(S): Mus musculus 
2013-12-11 | E-GEOD-48938 | biostudies-arrayexpress
TranscriptomicsCRISPR-mediated deletion of prostate cancer risk-associated CTCF loop anchors identifies repressive chromatin loops
Background: Recent genome-wide association studies (GWAS) have identified more than 100 loci associated with increased risk of prostate cancer, most of which are in non-coding regions of the genome. Understanding the function of these non-coding risk loci is critical to elucidate the genetic suscept...
ORGANISM(S): Homo sapiens 
2018-08-15 | GSE118514 | GEO
ProteomicsModeling of DNA methylation in cis reveals principles of chromatin folding in vivo in the absence of crosslinking and ligation
Mammalian chromosomes are folded into intricate hierarchies of interaction domains, within which topologically associating domains (TADs) and CTCF-associated loops partition the physical interactions between regulatory sequences. Current understanding of chromosome folding largely relies on chromoso...
ORGANISM(S): Mus musculus (Mouse) 
2019-06-03 | PXD013507 | Pride
Proteomic ruler Tads Chromosomal interactions Mouse embryonic stem cells Ctcf-associated loops Topologically associating domains Chromosome folding 
TranscriptomicsThe genomic landscape of cohesin-associated chromatin interactions
Cohesin is implicated in establishing tissue-specific DNA loops that target enhancers to promoters, and also localizes to sites bound by the insulator protein CTCF, which blocks enhancer-promoter communication. However, cohesin-associated interactions have not been characterized on a genome-wide sca...
ORGANISM(S): Mus musculus 
2013-05-22 | E-GEOD-42237 | biostudies-arrayexpress
UnknownZNF143 mediates CTCF-bound promoter-enhancer loops required for murine hematopoietic stem and progenitor cell function.
Not available
S-EPMC7782510 | biostudies-literature
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