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ProteomicsProtein stability changes reveal targets of pyrithione-induced Cu toxicity in E. coli
The biological activities of metals and ionophores have brought them to the forefront as potent antimicrobial and anticancer agents. However, the biological mechanisms behind these activities are not well understood. This work describes the first utilization of proteome-wide measurements of protein ...
ORGANISM(S): Escherichia coli 
2020-12-08 | PXD021198 | Pride
Cu toxicity Protein stability Pyrithione E. coli 
TranscriptomicsProfiling transcriptomic response of Enchytraeus albidus to Cu and Ni: Comparison with Cd and Zn
Metals, including copper (Cu) and nickel (Ni) are among the most common contaminants in soils in Europe. Although their effects are relatively well known regarding survival and reproduction of soil invertebrates, their modes of action in these organisms are still poorly studied. Enchytraeus albidus ...
ORGANISM(S): Enchytraeus albidus 
2013-12-31 | E-GEOD-47662 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Stickleback liver exposed to Cu, DbA (Dibezanthracene), EE2 (Ethinyl-estradiol) or relevant controls
Stickleback were exposed to Cu, DbA (Dibezanthracene), EE2 (Ethinyl-estradiol) or relevant controls. Pooled liver tissue from treatment groups exposed to different doses were arrayed versus a common reference.
ORGANISM(S): Gasterosteus aculeatus 
2009-07-10 | E-MAXD-43 | biostudies-arrayexpress
TranscriptomicsCopper-induced deregulation of microRNA expression in the zebrafish olfactory system
Although environmental trace metals, such as copper (Cu), can disrupt normal olfactory function in fish, the underlying molecular mechanisms of metal-induced olfactory injury have not been elucidated. Current research has suggested the involvement of epigenetic modifications. To address this hypothe...
ORGANISM(S): Danio rerio 
2014-04-30 | E-GEOD-46891 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver from sticklebacks exposed to copper, dibezanthracene or ethinyl-estradiol
Stickleback were exposed to Cu, DbA (Dibezanthracene), EE2 (Ethinyl-estradiol) or relevant controls. Liver tissue from individual fish exposed to different doses were arrayed versus a common reference.
ORGANISM(S): Gasterosteus aculeatus 
2009-07-10 | E-MAXD-42 | biostudies-arrayexpress
TranscriptomicsMolecular responses of human lung epithelial cells to the toxicity of copper oxide nanoparticles inferred from whole genome expression analysis.
This study proposes a molecular mechanism for lung epithelial A549 cell response to copper oxide nanoparticles (CuO-NPs) related to Cu ions released from CuO-NPs. Cells that survived exposure to CuO-NPs arrested the cell cycle as a result of the downregulation of proliferating cell nuclear antigen (...
ORGANISM(S): Homo sapiens 
2012-01-05 | E-GEOD-33278 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Danio rerio livers following chronic waterborne copper exposure
Zebrafish exposed to 2 waterborne copper concentrations (8 & 15 ug/L) in softwater for 21 days. Fish were terminally sampled and livers extracted for RNA extraction and hybridization to micorarrays
ORGANISM(S): Danio rerio 
2009-09-01 | E-MEXP-2287 | biostudies-arrayexpress
GenomicsCopper toxicity response influences mesotrophic Synechococcus community structure
Copper toxicity response influences mesotrophic Synechococcus community structure
PRJNA350850 | ENA
UnknownDevelopment of Cu(ii)-specific peptide shuttles capable of preventing Cu-amyloid beta toxicity and importing bioavailable Cu into cells.
Not available
S-EPMC9580518 | biostudies-literature
TranscriptomicsCopper toxicity response influences mesotrophic Synechococcus community structure
Picocyanobacteria from the genus Synechococcus are ubiquitous in ocean waters. Their phylogenetic and genomic diversity suggests ecological niche differentiation, but the selective forces influencing this are not well defined. Marine picocyanobacteria are sensitive to Cu toxicity, so adaptations to ...
ORGANISM(S): Synechococcus sp. CC9902 Bacteria Synechococcus sp. CC9311 
2016-10-28 | GSE89262 | GEO
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