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ProteomicsProtein stability changes reveal targets of pyrithione-induced Cu toxicity in E. coli
The biological activities of metals and ionophores have brought them to the forefront as potent antimicrobial and anticancer agents. However, the biological mechanisms behind these activities are not well understood. This work describes the first utilization of proteome-wide measurements of protein ...
ORGANISM(S): Escherichia coli 
2020-12-08 | PXD021198 | Pride
Cu toxicity Protein stability Pyrithione E. coli 
GenomicsUnderstanding the Mechanism of Action of the Anti-Dandruff Agent Zinc Pyrithione against Malassezia restricta.
Understanding the Mechanism of Action of the Anti-Dandruff Agent Zinc Pyrithione against Malassezia restricta.
PRJNA438989 | ENA
UnknownEffect of Combined Exposure to EDTA and Zinc Pyrithione on Pyrithione Absorption in Rats.
Not available
S-EPMC6467360 | biostudies-literature
TranscriptomicsZinc pyrithione treatment with 12.6 uM for 2 h
The number and type of synthetic chemicals that are being produced worldwide continues to increase significantly. While these industrial chemicals provide numerous benefits, there is no doubt that some have potential to damage the environment and health. Toxicity must be evaluated and use must be ca...
ORGANISM(S): Saccharomyces cerevisiae 
2007-11-01 | GSE9223 | GEO
UnknownCopper pyrithione and zinc pyrithione induce cytotoxicity and neurotoxicity in neuronal/astrocytic co-cultured cells via oxidative stress.
Not available
S-EPMC10754844 | biostudies-literature
UnknownMembrane Transporters Involved in the Antimicrobial Activities of Pyrithione in Escherichia coli.
Not available
S-EPMC8510280 | biostudies-literature
UnknownDual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating Mycobacterium tuberculosis.
Not available
S-EPMC7241432 | biostudies-literature
UnknownNovel Multifunctional Biosurfactant Obtained from Corn as a Stabilizing Agent for Antidandruff Formulations Based on Zn Pyrithione Powder.
Not available
S-EPMC7097895 | biostudies-literature
TranscriptomicsUnderstanding the Mechanism of Action of the Anti-Dandruff Agent Zinc Pyrithione against Malassezia restricta.
Purpose: Understanding the Mechanism of Action of the Anti-Dandruff Agent Zinc Pyrithione against Malassezia restricta. Methods: The transcriptome profile of the ZPT-treated M. restricta cells compared to that of untreated cells were generated by RNA-Seq using Illumina HiSeq. Generated raw reads tha...
ORGANISM(S): Malassezia restricta 
2018-12-25 | GSE112036 | GEO
UnknownZinc pyrithione inhibits yeast growth through copper influx and inactivation of iron-sulfur proteins.
Not available
S-EPMC3232817 | biostudies-literature
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