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ProteomicsReceptor-independent modulation of cAMP-dependent protein kinase and protein phosphatase 2A signaling in cardiac myocytes by nitroxyl
Sympathetic activation is the main driver of cardiac inotropy and lusitropy. Stimulation of the -adrenoceptor (AR) signaling cascade leads to activation of cAMP-dependent protein kinase (PKA) and subsequent cardiac protein phosphorylation, which is counteracted by the corresponding protein phosphata...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-10-29 | PXD019808 | Pride
Nitroxyl Cardiac myocyte Rat Oxidation Phosphatase Phosphorylation Kinase 
ProteomicsComparing the proteome of human induced pluripotent stem cells cultured during normoxic versus hypoxic conditions
Human induced pluripotent stem cells (hiPSCs) have become an invaluable tool to study molecular disease mechanisms on a human genetic background as they can be differentiated in different cell types including cardiac myocytes. One major downside that has decelerated the research performed in hiPSCs ...
ORGANISM(S): Homo sapiens (Human) 
2025-01-07 | PXD050410 | Pride
Normoxia Proteome remodeling Hypoxia Stem cells 
ProteomicsComplexome profiling of human induced pluripotent stem cells cultured during normoxic versus hypoxic conditions
Human induced pluripotent stem cells (hiPSCs) have become an invaluable tool for studying molecular disease mechanisms on a human genetic background. They can be differentiated into different cell types, including cardiac myocytes. Here, we studied the remodeling of mitochondrial protein complexes o...
ORGANISM(S): Homo sapiens (Human) 
2025-01-07 | PXD048535 | Pride
Normoxia Complexome remodeling Hypoxia Stem cells 
ProteomicsRedox-state of pentraxin 3 as a novel biomarker for resolution of inflammation and survival in sepsis
In an endotoxaemic mouse model of sepsis, a tissue-based proteomics approach for biomarker discovery identified long pentraxin 3 (PTX3) as the lead candidate for inflamed myocardium. PTX3 accumulated as an octamer due to disulphide-bond formation in heart, kidney and lung ?common organ dysfunctions ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2017-11-10 | MSV000081708 | MassIVE
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