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ProteomicsMouse HSC proteomics in basal or 5FU activated conditions
Proteomics of hemaopoietic stem cells under basal or 5FU activated conditions
ORGANISM(S): Mus musculus (Mouse) 
2022-02-16 | PXD021340 | Pride
Hsc Aging 
ProteomicsChaperone-mediated autophagy sustains hematopoietic stem cell function
Activation of mostly quiescent hematopoietic stem cells (HSC) is a prerequisite for life-long blood production1, 2. This process requires major molecular adaptations to meet the regulatory and metabolic requirements for cell division3-8. The mechanisms governing cellular reprograming upon stem cell ...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-05 | PXD022196 | Pride
Autophagy  chaperones  lipid metabolism  lysosomes  protein degradation  protein quality control  stem cells 
ProteomicsSILAC-based quantitative proteomics using mass spectrometry identifies BAG-6 mediated changes in the subproteome degraded by endosomal microautophagy (eMI).
To identify the subproteome degraded by endosomal microautophagy (eMI) in a Bag6-dependent manner, we compared the proteome of late endosomal compartments LE/MVBs isolated from control(wild type) and Bag6(-) cells using SILAC labeling and quantitative proteomics.
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD046760 | Pride
Mouse jaws Bag-6 ko Late endosomes 
ProteomicsIdentification of the late endosome LE/MVB proteome related to the endosomal microautophagy eMI activity in the rat liver.
To identify the late endosome LE/MVB proteome related to the endosomal microautophagy eMI activity we purified subcellular organelles including cytosol, late endosomes (LE/MVBs) and lysosomes (CMA+) from the rat liver and performed co-Ip experiment with antibodies directed against the major cellular...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-01-26 | PXD046797 | Pride
Cma vs microautophagy  hsc-70-co-ip-ms/ms in late endosomes Rat liver Lysosomes and cytosol 
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