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ProteomicsTargeting endoplasmic reticulum-anchored CRTH2 binding to LARP6 ameliorates organ fibrosis
Excessive deposition of extracellular matrix, mainly collagen protein, is the hallmark of organ fibrosis. The molecular mechanisms of the regulation of fibrotic protein biosynthesis are unclear. Here, we found that chemoattractant receptor homologous molecule expressed on TH2 cells (CRTH2), a cell m...
ORGANISM(S): Mus Sp. 
2021-04-25 | PXD025610 |
TranscriptomicsMyeloid derived suppressor cells enhance stemness of cancer cells by inducing miRNA101 and suppressing the corepressor CtBP2
The work identifies an immune associated cellular, molecular and clinical network involving MDSCs-microRNA101-CtBP2-stem cell core genes, which extrinsically controls cancer stemness and impacts patient outcome. Primary ovarian cancer cells (5 x105) were co-cultured with freshly sorted ovarian cance...
ORGANISM(S): Homo sapiens 
2013-08-23 | E-GEOD-50082 | biostudies-arrayexpress
ProteomicsA novel variant of Salmonella enterica serovar Typhimurium with a rough colony morphology and multidrug resistance
Salmonella enterica serovar Typhimurium (S. Typhimurium) is a major cause of salmonellosis, with various multidrug-resistant pathovariants emerging. Here, we investigated a distinct rough colony variant with potentially enhanced environmental adaptation in China. Whole-genome sequencing of 2,212 Chi...
ORGANISM(S): Salmonella Enterica Subsp. Enterica Serovar Typhimurium Str. Lt2 
2024-05-06 | PXD047483 |
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