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TranscriptomicsE2-RING expansion of the NEDD8 cascade confers specificity to cullin modification
Ubiquitin and ubiquitin-like proteins (UBLs) are directed to targets by cascades of E1, E2, and E3 enzymes. The largest ubiquitin E3 subclass consists of cullin-RING ligases (CRLs), which contain one each of several cullins (CUL1, -2, -3, -4, or -5) and RING proteins (RBX1 or -2). CRLs are activated...
ORGANISM(S): Mus musculus 
2009-03-23 | E-GEOD-14088 | biostudies-arrayexpress
GenomicsAdipose Cullin 3 knockout transcriptomics
Adipose Cullin 3 knockout transcriptomics
PRJNA1277188 | ENA
GenomicsLiver Cullin 3 knockout transcriptomics
Liver Cullin 3 knockout transcriptomics
PRJNA961690 | ENA
ProteomicsA cullin-RING ubiquitin ligase promotes thermotolerance as part of the Intracellular Pathogen Response in C. elegans.
Intracellular pathogen infection leads to proteotoxic stress in host organisms. Previously we described a physiological program in the nematode C. elegans called the Intracellular Pathogen Response (IPR), which promotes resistance to proteotoxic stress and appears to be distinct from canonical prote...
ORGANISM(S): Caenorhabditis Elegans (ncbitaxon:6239) 
2020-02-07 | MSV000084936 | MassIVE
ProteomicsCharacterisation of cullin E3 ubiquitin ligases in trypanosomes
Trypanosomes have seven cullin paralogs, the majority lineage-specific. Six of those cullins (TbCul-A, TbCul-C, TbCul-D TbCul-E, TbCul-F and TbCul-G) were endogenously 3xHA-epitope tagged at the C-terminus. We used affinity capture/mass spectrometry to determine the composition of these cullin compl...
ORGANISM(S): Trypanosoma brucei 
2024-03-25 | PXD042022 | Pride
Cullin Evolution Affinity isolation Protein turnover Ubiquitin Cryomilling E3 ligase 
GenomicsNEDDylated-Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors (ChIP-Seq)
NEDDylated-Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors (ChIP-Seq)
PRJNA875475 | ENA
GenomicsNEDDylated-Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors (RNA-Seq)
NEDDylated-Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors (RNA-Seq)
PRJNA875478 | ENA
TranscriptomicsLiver Cullin 3 knockout transcriptomics
To investigate the liver transcriptomics of WT and liver Cullin 3 KO mice on chow diect (CD) and Westrn diet (WD)
ORGANISM(S): Mus musculus 
2024-04-05 | GSE230518 | GEO
TranscriptomicsThe function of cullin 3 in macrophage
To further understanding the function of cullin 3 during inflammation in macrophages, we have employed mouse bone marrow derived macrophages microarray expression profiling to identify the gens that involve in regulationg inflammatory respones upon LPS challenge. Mouse BMM were stimulated with LPS f...
ORGANISM(S): Mus musculus 
2017-01-06 | GSE93166 | GEO
TranscriptomicsAdipose Cullin 3 knockout transcriptomics
To analyze the transcriptomic profiles of adipose tissue from wild-type (WT) and adipose-specific Cullin 3 knockout (KO) mice after 8 weeks on a Western diet (WD).
ORGANISM(S): Mus musculus 
2025-10-03 | GSE299865 | GEO
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