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Using bioinformatics, we identified TbTOM1, an ortholog of mammalian TOM1, a protein localising to endosomes. Using cryomilling and proteomics approaches we found interactor partners of TbTOM1, namely, Jerry.
ORGANISM(S): Trypanosoma brucei 
2026-08-24 | PXD058738 | Pride
Using cryomilling and proteomics approaches we expand the understanding of ESCRT-I complex in Trypanosoma brucei. We found two novel subunits of the trypanosoma complex using TbVPS23 as bait.
ORGANISM(S): Trypanosoma brucei 
2026-08-24 | PXD058826 | Pride
We affinity-purified VEX1GFP-associated proteins using cryomilling and high-affinity nanobodies. The procedure was carried out initially in insect-stage T. brucei, for which protocols were established, and then in bloodstream-form T. brucei. Quantitative proteomic analysis revealed tag-dependent enr...
ORGANISM(S): Trypanosoma brucei 
2019-05-31 | PXD013304 | Pride
UPF1-like helicases play roles in telomeric heterochromatin formation and X-chromosome inactivation and we focus here on variant surface glycoprotein (VSG) exclusion-factor-2 (VEX2), a UPF1-related protein in the African trypanosome. This bloodstream parasite evades host immunity by employing monoge...
ORGANISM(S): Trypanosoma brucei 
2023-11-20 | PXD040686 | Pride
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