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TranscriptomicsIdentification of genes expressed preferentially in the developing peripheral margin of the optic cup
Identification of genes expressed in a preferential manner in the developing ciliary body/iris will provide a starting point for future functional analyses. To identify candidate genes expressed in a variety of ocular tissues during development, we have profiled single cells from the developing eye...
ORGANISM(S): Mus musculus 
2009-05-01 | E-GEOD-15566 | biostudies-arrayexpress
TranscriptomicsWnt ligands from the embryonic surface ectoderm regulate bimetallic strip optic cup morphogenesis in the mouse
Wnt signaling in early eye development, specifically the lens placode shows expression of 12 out of 19 Wnt ligands. We these Wnt activities were suppressed using conditional deletion of Wntless, dramatic phenotypic changes in morphogensis occurred. Microarray analysis of the genes that were changed...
ORGANISM(S): Mus musculus 
2015-01-22 | E-GEOD-65154 | biostudies-arrayexpress
TranscriptomicsRNA-Seq data of terminal differentiated cells in Dictyostelium discoideum
The intent of the experiment was to gather transcriptomic data from terminally differentiated cell types --spore, stalk, and cup cells-- in a simple multicellular model system, Dictyostelium discoideum, in order to characterize the cell-type specific gene expression patterns. Specifically, we dissoc...
ORGANISM(S): Dictyostelium discoideum 
2019-01-31 | E-MTAB-7215 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of genes regulated by CUP-SHAPED COTYLEDON1 (CUC1) transcription factor in Arabidopsis thaliana
Samples 1 & 2: Comparison of gene expression between wild type (ecotype Ler) and 35S:CUC1, in which CUP-SHAPED COTYLEDON1, a master regulator of the shoot meristem and boundary establishment, is constitutively expressed under the cauliflower mosaic virus 35S promoter. Samples 3 & 4: Comparison of ge...
ORGANISM(S): Arabidopsis thaliana 
2011-03-30 | E-GEOD-27482 | biostudies-arrayexpress
UnknownAdding cetuximab to paclitaxel and carboplatin for first-line treatment of carcinoma of unknown primary (CUP): results of the Phase 2 AIO trial PACET-CUP.
Not available
S-EPMC7884392 | biostudies-literature
TranscriptomicsExpression analysis of cancer of unknown primary (CUP)
Biopsies (lymph nodes, ascites or hydrothorax) from 60 patients with cancer of unknown primary origin were analyzed. Results provide insight into the molecular pathogenesis of CUP. 60 samples; 1 array per sample
ORGANISM(S): Homo sapiens 
2012-11-20 | E-GEOD-42392 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of developing mouse eye (E11.5 and E12.5) comparing optic fissure margins with dorsal optic cup
We sought to identify gene expression signatures confined to the small group of cells at the fissure margins that are involved in OFC. Serial cryosections perpendicular to the optic fissure were prepared from mouse embryonic eyes (n=3 at E11.5 and n=3 at E12.5). The fissure margins and a correspondi...
ORGANISM(S): Mus musculus 
2020-12-17 | E-MTAB-9427 | biostudies-arrayexpress
TranscriptomicsRNA-seq of the developing human eye (Day 41-44 of embryonic development) comparing gene expression in ventral optic fissure margins with dorsal optic cup
We sought to identify gene expression signatures confined to the small group of cells at the fissure margins that are involved in OFC. Serial cryosections perpendicular to the optic fissure were prepared from human embryonic eyes (n=3, CS17-18, Day41-44(CS 17-18). The fissure margins and a correspon...
ORGANISM(S): Homo sapiens 
2020-12-17 | E-MTAB-9426 | biostudies-arrayexpress
TranscriptomicsCancers of unknown primary (CUP) are characterized by chromosomal instability (CIN) compared to metastasis of know origin.
Employing genome wide transcriptome analysis,Linear Discriminant Analysis (LDA) and Quadratic Discriminant Analysis (QDA), we created a successful classification model to identify the putative origin of a CUP. Using the classifications of the CUPs enable the comparison of transcriptome profiles from...
ORGANISM(S): Homo sapiens 
2015-05-31 | E-MTAB-3222 | biostudies-arrayexpress
GenomicsExpression analysis of cancer of unknown primary (CUP) 2
Expression analysis of cancer of unknown primary (CUP) 2
PRJNA517938 | ENA
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