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ProteomicsReactive oxygen species (ROS) production triggers unconventional secretion of antioxidant enzymes
Nutrient deprivation triggers the release of signal-sequence-lacking antioxidant superoxide dismutase 1 (SOD1). We now report that secreted SOD1 is functionally active and accompanied by export of other antioxidant enzymes such as thioredoxins, (Trx1 and Trx2) and peroxiredoxin Ahp1. Our data reveal...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-03-26 | PXD016815 | Pride
Proteomics Yeast Ros 
ProteomicsReactive oxygen species (ROS) production activates unconventional secretion of antioxidant proteins
Signal-sequence-lacking superoxide dismutase 1 (SOD1) is secreted upon nutrient starvation, but the physiological relevance of this secretion is unclear. We now report that secreted SOD1 is functionally active. In addition, a secretome analysis has revealed number of other secreted cytoplasmic antio...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-05-14 | PXD010849 | Pride
Unconventional secretion Ros Antioxidant 
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