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TranscriptomicsHuman transcriptome pattern of primary cutaneous lesions from patients with localized cutaneous leishmaniasis and mucosal leishmaniasis
We evaluated the trancriptome of primary cutaneous leisions caused by infection with Leishmania braziliensis. mRNA-seq technique was used to study the trancriptome of both host and parasite. A total of 10 samples was obtained from primary skin ulcers of two extreme clinical forms of American tegumen...
ORGANISM(S): Homo sapiens 
2012-10-24 | E-GEOD-33601 | biostudies-arrayexpress
ProteomicsComparative proteomic analysis of Leishmania parasite isolates obtained from visceral and cutaneous leishmaniases patients
As a vector-borne disease, leishmaniasis is caused by a parasitic protozoans of leishmania genus and transmitted by female Phlebotomine sandflies. Depending on the body location where immotile form of the parasite namely amastigote is proliferated, three main clinical forms as cutaneous, muco-cutane...
ORGANISM(S): Leishmania infantum Leishmania tropica 
2022-01-14 | PXD016333 | Pride
Leishmania Parasite Leishmaniasis Neglected tropical disease Sandfly Shotgun proteomics Leishmania infantum Leishmania tropica 
GenomicsA GWAS for cutaneous leishmaniasis in Brazil
Our goal was to identify genetic risk factors for cutaneous leishmaniasis (CL) caused by Leishmania braziliensis. Genotyping 2066 CL cases and 2046 controls using Illumina HumanCoreExomeBeadChips provided data for 4,498,586 imputed single nucleotide variants (SNVs). Genome-wide association testing...
EGAS00001004596 | EGA
MetabolomicsMining for natural product antileishmanials in a fungal extract library
Leishmaniasis is a Neglected Tropical Disease caused by the insect-vector borne protozoan parasite, Leishmania species. Infection affects millions of the World’s poorest, however vaccines are absent and drug therapy limited. Recently, public-private partnerships have developed to identify new modes ...
2021-02-12 | MTBLS868 | MetaboLights
TranscriptomicsExamining the genetic basis for visceral leishmaniasis disease: Comparison of distinct Leishmania donovani isolates that cause cutaneous and visceral leishmaniasis in Sri Lanka
Among the most central questions in Leishmania research is why some species remain in the skin dermis at the site of infection by the sand fly vector whereas other species migrate to visceral organs where they cause fatal visceral leishmaniasis. Although L. donovani is the species typically responsi...
ORGANISM(S): Leishmania donovani 
2013-12-31 | E-GEOD-48475 | biostudies-arrayexpress
TranscriptomicsGenetic introgression and transcriptomic plasticity are associated with enhanced Leishmania infantum pathogenicity causing human cutaneous leishmaniasis in Tunisia
The protozoan parasite Leishmania infantum exhibits significant genetic variability among isolates, influencing disease manifestation and treatment response. Although L. infantum is classically described as the causative agent of Visceral Leishmaniasis (VL) – often associated with immune deficiency,...
ORGANISM(S): Leishmania infantum 
2026-09-17 | E-MTAB-16364 | biostudies-arrayexpress
GenomicsNeutrophil-mediated hypoxia drives pathogenic CD8 T cell responses in cutaneous leishmaniasis
Neutrophil-mediated hypoxia drives pathogenic CD8 T cell responses in cutaneous leishmaniasis
PRJNA794119 | ENA
TranscriptomicsHuman transcriptome pattern of primary cutaneous lesions from patients with localized cutaneous leishmaniasis and mucosal leishmaniasis
We evaluated the trancriptome of primary cutaneous leisions caused by infection with Leishmania braziliensis. mRNA-seq technique was used to study the trancriptome of both host and parasite. A total of 10 samples was obtained from primary skin ulcers of two extreme clinical forms of American tegumen...
ORGANISM(S): Homo sapiens 
2012-10-24 | GSE33601 | GEO
GenomicsEarly reduction in PD-L1 expression predicts faster treatment response in human cutaneous leishmaniasis
Early reduction in PD-L1 expression predicts faster treatment response in human cutaneous leishmaniasis
PRJNA748034 | ENA
ProteomicsA Proteomic map of Leishmania donovani isolate from post kala-azar dermal leishmaniasis (PKDL) patient
In the present study, we carried out in-depth proteomic analysis of a clinical isolate of post kala-azar dermal leishmaniasis (PKDL) L. donovani promastigotes. The high-resolution mass spectrometry data was searched against protein database of L. donovani. This resulted in identification of 5, 283 u...
ORGANISM(S): Leishmania donovani Ld 2001 
2022-03-13 | PXD020541 | Pride
Kala-azar Kinetoplastids Phagolysosome Cutaneous leishmaniasis Intracellular parasite 
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