Cutaneous t-cell lymphoma

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Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Canada (2)
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Identification of AK4 and RHOC as novel oncogenes addicted by adult T-cell leukemia

Adult T-cell leukemia (ATL) is a highly aggressive T-cell malignancy characterized by human T-cell leukemia virus type 1 (HTLV-1) infection. ATL has a very poor prognosis and lacks satisfactory treatments; therefore, it is critical to identify novel targets in ATL cells in order to develop effective...

2025-02-03 | MTBLS11858 | MetaboLights

Transcription profiling of human skin biopsies in cutaneous T-cell lymphoma

Cutaneous T cell lymphoma (CTCL) is defined by infiltration of activated and malignant T cells in skin. The clinical manifestations and prognosis in CTCL are highly variable. In this study, we hypothesized that gene expression analysis in lesional skin biopsies can improve understanding of the disea...

ORGANISM(S): Homo sapiens

2008-06-16 | E-GEOD-9479 | biostudies-arrayexpress

Identification of AK4 and RHOC as novel oncogenes addicted by adult T-cell leukemia

2025-02-03 | MTBLS11844 | MetaboLights

Diagnostic microRNA profiling in cutaneous T-cell lymphoma (CTCL)

Cutaneous T-cell lymphomas (CTCL) are the most frequent primary skin lymphomas. Nevertheless, diagnosis of early disease has proven difficult due to a clinical and histological resemblance to benign inflammatory skin diseases. To address if microRNA (miRNA) profiling can discriminate CTCL from benig...

ORGANISM(S): Homo sapiens

2011-11-22 | E-GEOD-31408 | biostudies-arrayexpress

caArray_kuppe-00390: Broad: Lesional gene expression profiling in cutaneous T-cell lymphoma reveals natural clusters associated with disease outcome

Cutaneous T-cell lymphoma (CTCL) is defined by infiltration of activated and malignant T cells in the skin. The clinical manifestations and prognosis in CTCL are highly variable. In this study, we hypothesized that gene expression analysis in lesional skin biopsies can improve understanding of the d...

ORGANISM(S): Homo sapiens

2015-06-27 | E-GEOD-70328 | biostudies-arrayexpress

Gene Expression Profiles of cutaneous B-cell lymphoma

We studied gene expression profiles of 17 cutaneous B-cell lymphomas that were collected with 4-6 millimeter skin punch biopsies. We also included tissue from 2 cases of mycosis fungoides (MF), 3 normal skin biopsies and 3 tonsils to create a framework for further interpretation. A hierarchical clus...

ORGANISM(S): Homo sapiens

2005-12-16 | E-GEOD-3827 | biostudies-arrayexpress

Phenotypic and genomic analysis of an exceptional case of enteropathy associated T cell lymphoma

Approximately 2–5% of adult-onset coeliac disease (CD) patients develops refractory coeliac disease (RCD). In contrast to RCD type I, RCD type II is characterised by the presence of aberrant small intestinal intraepithelial T-lymphocytes (IEL) expressing cytoplasmic CD3 but lacking surface expressi...

ORGANISM(S): Homo sapiens

2010-06-17 | E-GEOD-17715 | biostudies-arrayexpress

Study of cutaneous biology of cutaneous T cell lymphoma

PRJNA785680 | ENA

Study of cutaneous biology of cutaneous T cell lymphoma

PRJNA785707 | ENA

Identification of genes that are regulated by TAK1 in human cutaneous T cell lymphoma HuT-102 cells

We previously reported that human T cell lymphotropic virus 1 (HTLV-1) Tax oncoprotein constitutively activates TAK1. Here, we established Tax-positive HuT-102 cells stably downregulated TAK1 expression by short-hairpin RNA (HuT-shTAK1 cells), and investigated the physiological function of TAK1. Mic...

ORGANISM(S): Homo sapiens

2009-08-18 | E-GEOD-16219 | biostudies-arrayexpress

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