Sort   by:  
 Page size 
We used a transmitochondrial cybrid (cybrids)-based discovery approach to identify mitochondria-regulated cancer pathways in TN BCa. Cybrids were generated under a moderately metastatic TN BCa cell line SUM159 as the common nuclear background with mitochondria from benign breast epithelium (A1N4) an...
ORGANISM(S): Homo sapiens 
RNA Sequencing of transmitochondrial cybrids
This dataset investigates the transcriptional effect of mitochondrial 12S rRNA hypermethylation, both by overexpressing the mitochondrial methyltransferase mtTFB1 in HeLa cells and by using A1555G cybrids, where the 12S rRNA is hypermethylated. HeLa cells overexpressing a methyltransferase-deficient...
ORGANISM(S): Homo sapiens 
RNA Sequencing of transmitochondrial cybrids revealed a downregulation of oxidative phosphorylation and nicotinamide metabolism in cybrids with patient mitochondria
ORGANISM(S): Homo sapiens 
2022-10-19 | GSE215859 | GEO
Reciprocal cybrids reveal how organellar genomes affect plant phenotypes
Reciprocal cybrids reveal how organellar genomes affect plant phenotypes
Transcriptome profiling of cybrids cells with and without m.14487T>C mutation
Mitochondrial respiratory chain (MRC) complexes I, III and IV are associated into large molecular structures named supercomplexes (SCs) or respirasomes, whose functional roles remain to be fully understood. Biochemical analyses in a diversity of OXPHOS-deficient cellular and animal models support th...
ORGANISM(S): Homo sapiens (Human) 
2020-07-01 | PXD017840 | Pride
This dataset investigates the transcriptional effect of mitochondrial 12S rRNA hypermethylation, both by overexpressing the mitochondrial methyltransferase mtTFB1 in HeLa cells and by using A1555G cybrids, where the 12S rRNA is hypermethylated. HeLa cells overexpressing a methyltransferase-deficient...
ORGANISM(S): Homo sapiens 
2012-09-18 | GSE33780 | GEO
Transcriptome profiling is a sensitive strategy to uncover the change of mitochondrial to nucleus signaling due to the minor alternation of mitochondrial OXPHOS function. Therefore, we hypothesized that even a minor alternation of OXPHOS function can also remold transcriptome profiles in m.14487T>C ...
ORGANISM(S): Homo sapiens 
2020-05-19 | GSE131739 | GEO
Sort   by:  
 Page size