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TranscriptomicsTranscription profiling of human bladder smooth muscle cells subjected to cyclic stretch-relaxation
The aim of the experiment was to determine the effect of cyclic stretch-relaxation ("stretch") on gene expression patterns in normal diploid human bladder smooth muscle cells. Cells plated on silicone elastomer bottomed 6-well culture dishes were grown to ~80% confluence, serum-depleted for 48h and ...
ORGANISM(S): Homo sapiens 
2007-08-04 | E-GEOD-1595 | biostudies-arrayexpress
TranscriptomicsThe ion channel Trpc6a regulates the cardiomyocyte regenerative response to mechanical stretch
Myocardial damage caused for example by cardiac ischemia leads to ventricular volume overload resulting in increased stretch of the remaining myocardium. In adult mammals, these changes trigger an adaptive cardiomyocyte hypertrophic response which, if the damage is extensive, will ultimately lead to...
ORGANISM(S): Danio rerio 
2023-12-20 | E-MTAB-13603 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human bronchial epithelial cells exposed to cyclic stretch with and without LPS or TNFa
Acute respiratory distress syndrome (ARDS) is a catastrophic form of acute lung injury (ALI). The necessity for mechanical ventilation (MV) renders patients at risk for ventilator induced lung injury (VILI). Exposure to repetitive cyclic stretch (CS) and/or over-inflation exacerbates injury. Reducin...
ORGANISM(S): Homo sapiens 
2009-09-15 | E-GEOD-16650 | biostudies-arrayexpress
TranscriptomicsComparison of human aortic valve interstitial cells (AVICs) exposed to cyclic stretch to static samples
AVICs were exposed to cyclic stretch to examine the role of mechanical stimuli on gene expression AVICs cultured on collagen 1 coated Bioflex were exposed to 14% stretch at 1 hz or static conditions using a Flexcell-5000 14% stretch was the experimental condition while the static condition was the c...
ORGANISM(S): Homo sapiens 
2015-01-09 | E-GEOD-47687 | biostudies-arrayexpress
ProteomicsPhosphoproteome of cyclic stretch A549 and IMR-90
Lung cancer is one of the leading causes of death. However, most of the researches were based on the traditional cell-culturing method. Whereas cells of lung are subjected to the mechanical forces periodically while breathing. In the present study, we applied cyclic stretch to stimulate the continuo...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD012010 | Pride
Phosphoproteome  cyclic stretch  lund cancer  lung fibroblast 
TranscriptomicsCyclic mechanical stretch-induced gene expression
With gene expression profiling it was aimed to identify the differentially expressed genes associated with the regulation of the cytoskeleton to investigate the stretch-induced cell alignment mechanism. A whole genome microarray based analysis of the stretch-induced gene expression changes was done....
ORGANISM(S): Homo sapiens 
2014-06-11 | E-GEOD-58389 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human A549 cell line activated with either cyclic stretch (20% elongation), tumor necrosis factor or lipopolysaccharide
Alveolar epithalial cells (A549) were used as a model of pulmonary parenchymal cell activation to quiery gene expression profile of activation with either cyclic stretch (20% elongation), TNF (20 ng/ml), LPS (1 mcg/ml) or TNF+STRETCH at both 1 and 4 hrs.
ORGANISM(S): Homo sapiens 
2007-08-04 | E-GEOD-1541 | biostudies-arrayexpress
ProteomicsMulti-omics analyses reveal the mechanical-stress-dependent changes in trabecular meshwork cytoskeletal-extracellular matrix interactions
Trabecular meshwork (TM) tissue is subjected to constant mechanical stress due to the ocular pulse created by the cardiac cycle. This induces alterations in membrane lipids and associated cell-cell adhesion and cell-extracellular matrix (ECM) interactions triggering intracellular signaling responses...
ORGANISM(S): Homo sapiens (Human) 
2022-08-30 | PXD031347 | Pride
Cyclic mechanical stretch Human trabecular meshwork Global proteomic analysis (lc-ms/ms) Mrna sequencing. Lipidomic analysis 
TranscriptomicsExpression data from cultured rat right ventricular papillary muscles
Several different mechanical signals have been proposed to control the extent and pattern of myocardial growth and remodeling, though this has largely been studied using in vitro model systems that are not representative of intact myocardium or in vivo models in which isolating the effects of indivi...
ORGANISM(S): Rattus norvegicus 
2013-03-19 | E-GEOD-45250 | biostudies-arrayexpress
TranscriptomicsCyclic mechanical stretch-induced gene expression
With gene expression profiling it was aimed to identify the differentially expressed genes associated with the regulation of the cytoskeleton to investigate the stretch-induced cell alignment mechanism. A whole genome microarray based analysis of the stretch-induced gene expression changes was done....
ORGANISM(S): Homo sapiens 
2014-06-11 | GSE58389 | GEO
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