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Staphylococcus aureus is an opportunistic pathogen capable of causing various infections ranging from superficial skin infections to life-threatening severe diseases, including pneumonia and sepsis. This bacterium is attached to biotic and abiotic surfaces and forms biofilms that are resistant to co...
ORGANISM(S): Staphylococcus aureus 
This dataset contains raw LC–MS/MS data and associated search results generated for the identification and characterization of proteome-derived cyclic peptides produced via ortho-phthalaldehyde (OPA)-mediated macrocyclization. Cysteine-containing peptides derived from human proteome digests were sel...
ORGANISM(S): Homo sapiens (Human) 
2026-09-03 | PXD074548 | Pride
Rapid discovery of cyclic peptide protein aggregation inhibitors through continuous selection HTS data
To enhance local drug delivery and therapeutic efficacy, we developed a novel synthetic protein by fusing a collagen-binding domain (CBD) to C-type natriuretic peptide (CNP), termed CBD-CNP. CBD-CNP localized to collagen-rich tissues and promoted bone elongation.
ORGANISM(S): Mus musculus 
Mitochondria are known to be functional organelles, but their role as a signaling unit is increasingly being appreciated. The recent identification of a short open reading frame (sORF) in the mitochondrial DNA (mtDNA) that encodes a signaling peptide, humanin, suggests the possible existence of addi...
ORGANISM(S): Homo sapiens 
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