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TranscriptomicsTranscription profiling by array of human non-activated MM6 cells with cyclin T1 knockdown
Cyclin T1-dependent genes in LPS-activated MM6 cells. HIV-1 is dependent upon cellular co-factors to mediate its replication cycle in CD4+ T cells and macrophages, the two major cell types infected by the virus in vivo. One critical co-factor is Cyclin T1, a subunit of a general RNA polymerase II ...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-10738 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human PMA-activated Jurkat cells
Cyclin T1-dependent genes in activated Jurkat cells. HIV-1 is dependent upon cellular co-factors to mediate its replication cycle in CD4+ T cells and macrophages, the two major cell types infected by the virus in vivo. One critical co-factor is Cyclin T1, a subunit of a general RNA polymerase II el...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-10232 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human LPS-activated MM6 cells with Cyclin D1 knockdown
Cyclin T1-dependent genes in LPS-activated MM6 cells. HIV-1 is dependent upon cellular co-factors to mediate its replication cycle in CD4+ T cells and macrophages, the two major cell types infected by the virus in vivo. One critical co-factor is Cyclin T1, a subunit of a general RNA polymerase II e...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-10234 | biostudies-arrayexpress
TranscriptomicsCTDG in PMA-activated MM6 cells
Cyclin T1-dependent genes in PMA-activated MM6 cells. HIV-1 is dependent upon cellular co-factors to mediate its replication cycle in CD4+ T cells and macrophages, the two major cell types infected by the virus in vivo. One critical co-factor is Cyclin T1, a subunit of a general RNA polymerase II e...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-10233 | biostudies-arrayexpress
ProteomicsCell cycle phosphorylation dynamics in vivo reveals switch-like control of intrinsic disorder
Switch-like cyclin-dependent kinase (CDK)-1 activation is thought to underlie the abruptness of mitotic onset, but how CDKs can simultaneously phosphorylate many diverse substrates is unknown, and direct evidence for such phosphorylation dynamics in vivo is lacking. Here, we analysed protein phospho...
ORGANISM(S): Xenopus Laevis 
PXD026088 | panorama
GenomicsChIP-seq of cyclin-dependent kinases
ChIP-seq of cyclin-dependent kinases
PRJNA257298 | ENA
TranscriptomicsTranscription profiling of human peripheral blood mononuclear cells treated with a CDK inhibitor
A genomics-based approach to identify pharmacodynamic biomarkers was used for a CDK (cyclin-dependent kinase) inhibitory drug. R547 is a potent CDK inhibitor with a potent anti-proliferative effect at pharmacologically relevant doses, and is currently in Phase I clinical trials. Utilizing preclinic...
ORGANISM(S): Homo sapiens 
2009-03-28 | E-GEOD-15389 | biostudies-arrayexpress
GenomicsChIP-seq of cyclin-dependent kinases
Several cyclin-dependent kinases (CDKs) are known to have roles in transcriptional regulation.  The datasets presented here are ChIP-seq experiments for different CDKs and RNA polymerase II in murine embryonic stem cells and Jurkat cells. ChIP-Seq of cyclin-dependent kinases in mouse embryonic stem ...
ORGANISM(S): Homo sapiens 
2014-08-03 | E-GEOD-60027 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of an E2F gene signature as a biomarker of activity of the cyclin-dependent kinase inhibitor PHA-793887 in tumor and skin biopsies from a phase I clinical study
Microarray analysis of transcriptional changes in biopsies of solid tumors from patients treated in a Phase I study with the Cdk inhibitor PHA-793887. 7 patient biopsies pre- and post-treatment in dye swap. Tumors are of different origins, and are described in the accompanying manuscript.
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-18553 | biostudies-arrayexpress
ProteomicsIdentification of CDK1 substrates in mitosis by quantitative phosphoproteomics
Cyclin-dependent kinase 1 (Cdk1) is an essential regulator of many mitotic processes including the reorganization of the cytoskeleton, chromosome segregation, and formation and separation of daughter cells. Deregulation of Cdk1 activity results in defects in these processes. Although the role of Cdk...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-02-24 | MSV000079528 | MassIVE
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